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Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score.

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Title: Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score.
Authors: Deutsch AJ; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Bell AS; Department of Medicine, Harvard Medical School, Boston, MA, USA., Michalek DA; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA., Burkholder AB; Office of Environmental Science Cyberinfrastructure, National Institute of Environmental Health Sciences, Durham, NC, USA., Nam S; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kreienkamp RJ; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA., Sharp SA; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huerta-Chagoya A; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Mandla R; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Graduate Program in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Nanjala R; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Luo Y; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Oram RA; University of Exeter College of Medicine and Health, Exeter, UK.; Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK., Florez JC; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Onengut-Gumuscu S; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA., Rich SS; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA., Motsinger-Reif AA; Biostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA., Manning AK; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA., Mercader JM; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Udler MS; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Jun 22. Date of Electronic Publication: 2025 Jun 22.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kreienkamp+RJ%22">Kreienkamp RJ</searchLink>; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sharp+SA%22">Sharp SA</searchLink>; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; 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Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Luo+Y%22">Luo Y</searchLink>; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Oram+RA%22">Oram RA</searchLink>; University of Exeter College of Medicine and Health, Exeter, UK.; Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Florez+JC%22">Florez JC</searchLink>; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Onengut-Gumuscu+S%22">Onengut-Gumuscu S</searchLink>; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Rich+SS%22">Rich SS</searchLink>; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Motsinger-Reif+AA%22">Motsinger-Reif AA</searchLink>; Biostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Manning+AK%22">Manning AK</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mercader+JM%22">Mercader JM</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Udler+MS%22">Udler MS</searchLink>; Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
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