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Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor.

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Title: Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor.
Authors: Bardiot D; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium., McGowan DC; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Gupta K; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Deval J; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Chang S; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Jekle A; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Liu C; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Stevens S; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Serebryany V; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Tauchert MJ; Proteros Biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany., Maskos K; Proteros Biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany., Stoycheva AD; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Ren S; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Jaisinghani R; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Faucher MO; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Lin TI; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Boland S; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium., Chaltin P; Centre for Drug Design and Discovery (CD3), KU Leuven, Gaston Geenslaan 2, 3001 Leuven, Belgium.; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium., Marchand A; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium., Wuyts J; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium., De Jonghe S; Virology, Antiviral Drug & Vaccine Research Group, Department of Microbiology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium., Jochmans D; Virology, Antiviral Drug & Vaccine Research Group, Department of Microbiology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium., Anugu S; Aragen Lifesciences Pvt. Ltd, Survey No: 125 & 126, IDA Mallapur, Hyderabad 500076, India., Baloju V; Aragen Lifesciences Pvt. Ltd, Survey No: 125 & 126, IDA Mallapur, Hyderabad 500076, India., Deta K; Aragen Lifesciences Pvt. Ltd, Survey No: 125 & 126, IDA Mallapur, Hyderabad 500076, India., Welch M; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Leyssen P; Virology, Antiviral Drug & Vaccine Research Group, Department of Microbiology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium., Neyts J; Virology, Antiviral Drug & Vaccine Research Group, Department of Microbiology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.; VirusBank Platform, Virology, Antiviral Drug & Vaccine Research Group, Department of Microbiology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium., Laporte M; Virology, Antiviral Drug & Vaccine Research Group, Department of Microbiology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium., Abdelnabi R; VirusBank Platform, Virology, Antiviral Drug & Vaccine Research Group, Department of Microbiology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium., Hu H; Pharmaron, 6 Taihe Road, BDA, Beijing 100176, China., Zhang P; Pharmaron, 6 Taihe Road, BDA, Beijing 100176, China., Le K; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Chanda S; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Smith DB; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Raboisson P; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Beigelman L; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Symons JA; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Blatt L; Aligos Therapeutics, Inc., 1 Corporate Drive, South San Francisco, California 94080, United States., Vandyck K; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Jul 10; Vol. 68 (13), pp. 13436-13454. Date of Electronic Publication: 2025 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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