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Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross-sectional associations with early cognitive impairments.

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Title: Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross-sectional associations with early cognitive impairments.
Authors: Fu JF; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Garimella A; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Lapointe A; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Aye WWT; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Chen CD; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Lee JH; Departments of Neurology and Epidemiology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA., Krinsky-McHale SJ; Department of Psychology, The New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA., Zaman S; Department of Psychiatry, University of Cambridge, Cambridge, UK., Lott IT; Department of Pediatrics, University of California, Irvine, California, USA., Hom C; Department of Psychiatry and Human Behavior, University of California, Irvine, California, USA., Ances B; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Head E; Department of Pathology, University of California, Irvine, California, USA., Mapstone M; Department of Neurology, University of California, Irvine, California, USA., Lai F; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Handen BL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Laymon CM; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hartley SL; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Christian BT; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Rentz DM; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Johnson KA; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Rosas HD; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Price JC; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Corporate Authors: Alzheimer Biomarkers Consortium–Down Syndrome (ABC‐DS)
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Jul; Vol. 21 (7), pp. e70424.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross-sectional associations with early cognitive impairments.
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  Data: <searchLink fieldCode="AU" term="%22Fu+JF%22">Fu JF</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Garimella+A%22">Garimella A</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lapointe+A%22">Lapointe A</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Aye+WWT%22">Aye WWT</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Chen+CD%22">Chen CD</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Departments of Neurology and Epidemiology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Krinsky-McHale+SJ%22">Krinsky-McHale SJ</searchLink>; Department of Psychology, The New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zaman+S%22">Zaman S</searchLink>; Department of Psychiatry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lott+IT%22">Lott IT</searchLink>; Department of Pediatrics, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Hom+C%22">Hom C</searchLink>; Department of Psychiatry and Human Behavior, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Ances+B%22">Ances B</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Head+E%22">Head E</searchLink>; Department of Pathology, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Mapstone+M%22">Mapstone M</searchLink>; Department of Neurology, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Lai+F%22">Lai F</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Handen+BL%22">Handen BL</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Laymon+CM%22">Laymon CM</searchLink>; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Hartley+SL%22">Hartley SL</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Christian+BT%22">Christian BT</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Rentz+DM%22">Rentz DM</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+KA%22">Johnson KA</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Rosas+HD%22">Rosas HD</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Price+JC%22">Price JC</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
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  Data: <searchLink fieldCode="CA" term="%22Alzheimer+Biomarkers+Consortium–Down+Syndrome+%28ABC‐DS%29%22">Alzheimer Biomarkers Consortium–Down Syndrome (ABC‐DS)</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2025 Jul; Vol. 21 (7), pp. e70424.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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        Value: 10.1002/alz.70424
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              Text: 2025 Jul
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