Understanding the interaction of upper respiratory tract infection with respiratory syncytial virus and Streptococcus pneumoniae using a human challenge model: a multicenter, randomized controlled study protocol.
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| Title: | Understanding the interaction of upper respiratory tract infection with respiratory syncytial virus and Streptococcus pneumoniae using a human challenge model: a multicenter, randomized controlled study protocol. |
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| Authors: | Brito-Mutunayagam S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Hamilton DO; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Mitsi E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Solórzano C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Li G; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Rocha De Macedo B; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Elterish F; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Liu X; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Tanha K; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., White R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Hyder-Wright A; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Patel B; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Urban BC; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Whelan C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Trari Belhadef H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Robinson H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Plested E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Thompson A; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Lahuerta M; Pfizer Vaccines, Pfizer Inc, New York, New York, United States of America., Kanevsky I; Pfizer Vaccines, Pfizer Inc, New York, New York, United States of America., Swanson K; Pfizer Vaccines, Pfizer Inc, New York, New York, United States of America., Aliabadi N; Pfizer Vaccines, Pfizer Inc, New York, New York, United States of America., Catusse J; Pfizer Vaccines, Pfizer Inc, New York, New York, United States of America., Theilacker C; Pfizer Vaccines, Pfizer Inc, New York, New York, United States of America., Gessner BD; Pfizer Vaccines, Pfizer Inc, New York, New York, United States of America., Mazur NI; Department of Pediatric Infectious Diseases and Immunology, University Medical Centre Utrecht, Utrecht, Netherlands., Chiu C; Department of Infectious Disease, Imperial College London, London, United Kingdom., Collins AM; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.; University Hospital Liverpool Group, Liverpool, United Kingdom., Morton B; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Ramasamy MN; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Ferreira DM; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom. |
| Source: | PloS one [PLoS One] 2025 Jul 01; Vol. 20 (7), pp. e0325149. Date of Electronic Publication: 2025 Jul 01 (Print Publication: 2025). |
| Publication Type: | Clinical Trial Protocol; Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40591700 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Understanding the interaction of upper respiratory tract infection with respiratory syncytial virus and Streptococcus pneumoniae using a human challenge model: a multicenter, randomized controlled study protocol. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Brito-Mutunayagam+S%22">Brito-Mutunayagam S</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hamilton+DO%22">Hamilton DO</searchLink>; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mitsi+E%22">Mitsi E</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Solórzano+C%22">Solórzano C</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rocha+De+Macedo+B%22">Rocha De Macedo B</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Elterish+F%22">Elterish F</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tanha+K%22">Tanha K</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22White+R%22">White R</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hyder-Wright+A%22">Hyder-Wright A</searchLink>; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Patel+B%22">Patel B</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Urban+BC%22">Urban BC</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Whelan+C%22">Whelan C</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Trari+Belhadef+H%22">Trari Belhadef H</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Robinson+H%22">Robinson H</searchLink>; 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