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A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins.

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Title: A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins.
Authors: Sharapov S; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., Timoshchuk A; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., Zaytseva O; Genos Glycoscience Research Laboratory, Borongajska cesta 83H, Zagreb, Croatia., Maslov DE; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., Soplenkova A; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., Elgaeva EE; Institute of Cytology and Genetics, Novosibirsk, Russia.; Novosibirsk State University, Novosibirsk, Russia., Tiys ES; Institute of Cytology and Genetics, Novosibirsk, Russia., Mangino M; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, St Thomas' Campus, Lambeth Palace Road, London, United Kingdom.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, United Kingdom., Wittenbecher C; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Karssen L; PolyOmica, 's-Hertogenbosch, Hertogenbosch, PA, The Netherlands., Timofeeva M; Colon Cancer Genetics Group, Cancer Research UK Scotland Centre, Institute of Genetics & Cancer, Western General Hospital, The University of Edinburgh, Edinburgh, United Kingdom.; D-IAS, Danish Institute for Advanced Study, Department of Public Health, University of Southern Denmark, J.B. Winsløws Vej 9, Odense C, Denmark., Nostaeva A; Institute of Cytology and Genetics, Novosibirsk, Russia.; PolyOmica, 's-Hertogenbosch, Hertogenbosch, PA, The Netherlands., Vuckovic F; Genos Glycoscience Research Laboratory, Borongajska cesta 83H, Zagreb, Croatia., Trbojević-Akmačić I; Genos Glycoscience Research Laboratory, Borongajska cesta 83H, Zagreb, Croatia., Štambuk T; Genos Glycoscience Research Laboratory, Borongajska cesta 83H, Zagreb, Croatia., Feoktistova S; Institute of Cytology and Genetics, Novosibirsk, Russia., Potapova NA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Voroshilova V; Institute of Cytology and Genetics, Novosibirsk, Russia.; Vavilov Institute of General Genetics Russian Academy of Sciences, Moscow, Russia., Williams F; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, St Thomas' Campus, Lambeth Palace Road, London, United Kingdom., Primorac D; St. Catherine Specialty Hospital, Ulica Kneza Branimira, 71E, Zagreb, Croatia.; University of Split School of Medicine, Split, Croatia.; University of Osijek School of Medicine, Osijek, Croatia., Van Zundert J; Department of Anesthesiology and Multidisciplinary Paincentre, ZOL, Genk, Lanaken, Belgium.; Department of Anesthesiology and Pain Medicine, Maastricht University Medical Centre, P. Debyelaan 25, Maastricht, The Netherlands., Georges M; Unit of Animal Genomics, WELBIO, GIGA-R and Faculty of Veterinary Medicine, University of Liège, (B34) 1 Avenue de l'Hôpital, Liège, Belgium., Suhre K; Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar., Allegri M; Centre Lemanique d'antalgie et neuromodulation - EHC, Morges, Switzerland., Chaturvedi N; MRC Unit for Lifelong Health & Ageing University College London, London, United Kingdom., Dunlop M; Colon Cancer Genetics Group, Cancer Research UK Scotland Centre, Institute of Genetics & Cancer, Western General Hospital, The University of Edinburgh, Edinburgh, United Kingdom., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke, 14558, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Nutrition Science, University of Potsdam, Potsdam, Germany., Spector T; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, St Thomas' Campus, Lambeth Palace Road, London, United Kingdom., Tsepilov YA; Institute of Cytology and Genetics, Novosibirsk, Russia.; Wellcome Sanger Institute, Cambridge, United Kingdom., Lauc G; Genos Glycoscience Research Laboratory, Borongajska cesta 83H, Zagreb, Croatia.; University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia., Aulchenko YS; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia. yurii@bionet.nsc.ru.; Institute of Cytology and Genetics, Novosibirsk, Russia. yurii@bionet.nsc.ru.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5525. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-60431-y