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Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline.

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Title: Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline.
Authors: Choby JE; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Atlanta, GA, USA., Ozturk T; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Atlanta, GA, USA., Abbott CN; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Atlanta, GA, USA., Nnabuife C; Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA., Colquhoun JM; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.; Research Service, Atlanta VA Medical Center, Decatur, GA, USA., Satola SW; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Georgia Emerging Infections Program, Atlanta, GA, USA., Rather PN; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.; Research Service, Atlanta VA Medical Center, Decatur, GA, USA., Palzkill T; Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA., Weiss DS; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA. david.weiss@emory.edu.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. david.weiss@emory.edu.; Emory Vaccine Center, Atlanta, GA, USA. david.weiss@emory.edu.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5721. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline.
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  Data: <searchLink fieldCode="AU" term="%22Choby+JE%22">Choby JE</searchLink>; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ozturk+T%22">Ozturk T</searchLink>; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Abbott+CN%22">Abbott CN</searchLink>; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Nnabuife+C%22">Nnabuife C</searchLink>; Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Colquhoun+JM%22">Colquhoun JM</searchLink>; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.; Research Service, Atlanta VA Medical Center, Decatur, GA, USA.<br /><searchLink fieldCode="AU" term="%22Satola+SW%22">Satola SW</searchLink>; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Georgia Emerging Infections Program, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Rather+PN%22">Rather PN</searchLink>; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.; Research Service, Atlanta VA Medical Center, Decatur, GA, USA.<br /><searchLink fieldCode="AU" term="%22Palzkill+T%22">Palzkill T</searchLink>; Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+DS%22">Weiss DS</searchLink>; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA. david.weiss@emory.edu.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. david.weiss@emory.edu.; Emory Vaccine Center, Atlanta, GA, USA. david.weiss@emory.edu.
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