Merging the computational design of chimeric type I polyketide synthases with enzymatic pathways for chemical biosynthesis.
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| Title: | Merging the computational design of chimeric type I polyketide synthases with enzymatic pathways for chemical biosynthesis. |
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| Authors: | Chainani Y; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Evanston, IL, USA.; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Diaz J; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Guilarte-Silva M; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Evanston, IL, USA., Blay V; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Zhang Q; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA., Sprague W; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA., Tyo KEJ; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Evanston, IL, USA., Broadbelt LJ; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Evanston, IL, USA.; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Mukhopadhyay A; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Keasling JD; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; QB3, University of California, Berkeley, CA, USA.; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA.; Department of Bioengineering, University of California, Berkeley, CA, USA.; Center for Biosustainability, Danish Technical University, Lynby, Denmark., Martin HG; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; BCAM, Basque Center for Applied Mathematics, Bilbao, Spain.; DOE Agile BioFoundry, Emeryville, CA, USA., Backman TWH; Joint BioEnergy Institute, Emeryville, CA, USA. tbackman@lbl.gov.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. tbackman@lbl.gov. |
| Source: | Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5787. Date of Electronic Publication: 2025 Jul 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-61160-y |
