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Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer's disease.

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Title: Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer's disease.
Authors: Rohden F; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Ferreira PCL; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Bellaver B; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Ferrari-Souza JP; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Aguzzoli CS; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Brain Institute of Rio Grande do Sul, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil.; Global Brain Health Institute, University of California, San Francisco, USA., Soares C; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Abbas S; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Zalzale H; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Povala G; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Lussier FZ; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Leffa DT; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Bauer-Negrini G; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Rahmouni N; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada., Tissot C; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada., Therriault J; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada., Servaes S; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada., Stevenson J; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada., Benedet AL; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden., Ashton NJ; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Karikari TK; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden., Tudorascu DL; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Biostatistics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Zetterberg H; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Blennow K; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden., Zimmer ER; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Brain Institute of Rio Grande do Sul, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil.; Graduate Program in Biological Sciences: Pharmacology and Therapeuctis, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Souza D; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Rosa-Neto P; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada., Pascoal TA; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. pascoalt@upmc.edu.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. pascoalt@upmc.edu.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5653. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Rohden+F%22">Rohden F</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Ferreira+PCL%22">Ferreira PCL</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bellaver+B%22">Bellaver B</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ferrari-Souza+JP%22">Ferrari-Souza JP</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Aguzzoli+CS%22">Aguzzoli CS</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Brain Institute of Rio Grande do Sul, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil.; Global Brain Health Institute, University of California, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Soares+C%22">Soares C</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Abbas+S%22">Abbas S</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zalzale+H%22">Zalzale H</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Povala+G%22">Povala G</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lussier+FZ%22">Lussier FZ</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Leffa+DT%22">Leffa DT</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bauer-Negrini+G%22">Bauer-Negrini G</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rahmouni+N%22">Rahmouni N</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Tissot+C%22">Tissot C</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Therriault+J%22">Therriault J</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Servaes+S%22">Servaes S</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Stevenson+J%22">Stevenson J</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Benedet+AL%22">Benedet AL</searchLink>; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Ashton+NJ%22">Ashton NJ</searchLink>; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Karikari+TK%22">Karikari TK</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Tudorascu+DL%22">Tudorascu DL</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Biostatistics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Zimmer+ER%22">Zimmer ER</searchLink>; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Brain Institute of Rio Grande do Sul, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil.; Graduate Program in Biological Sciences: Pharmacology and Therapeuctis, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Souza+D%22">Souza D</searchLink>; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Rosa-Neto+P%22">Rosa-Neto P</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Pascoal+TA%22">Pascoal TA</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. pascoalt@upmc.edu.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. pascoalt@upmc.edu.
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