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A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis.

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Title: A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis.
Authors: Li K; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA., Rudy MJ; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA., Hu Y; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA., Tan H; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA., Lambrinidis G; Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, Athens, 15771, Greece., Wu X; Department of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ, USA., Georgiou K; Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, Athens, 15771, Greece., Tan B; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA., Frost J; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA., Wilson C; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA., Clarke P; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA., Kolocouris A; Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, Athens, 15771, Greece., Zhang QY; Department of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ, USA., Tyler KL; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA. ken.tyler@cuanschutz.edu.; Department of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO, USA. ken.tyler@cuanschutz.edu.; Division of Infectious Disease, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA. ken.tyler@cuanschutz.edu.; Neurology Service, Rocky Mountain VA Medical Center, Aurora, CO, USA. ken.tyler@cuanschutz.edu., Wang J; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA. junwang@pharmacy.rutgers.edu.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5987. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis.
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