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Dual treatment with Val-083 and AZD1775 shows potent anti-tumor activity in diffuse midline glioma models.

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Title: Dual treatment with Val-083 and AZD1775 shows potent anti-tumor activity in diffuse midline glioma models.
Authors: Subramaniam B; Brain Tumor Institute, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA., Roy D; Brain Tumor Institute, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA., Woldegerima A; Brain Tumor Institute, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA., Chong WC; Brain Tumor Institute, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA., Przystal JM; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland., Zhang J; Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Laternser S; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland., Kritzer B; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland., Rangnath S; University of Michigan, Ann Arbor, MI, USA., Knowles T; Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Yadavilli S; Brain Tumor Institute, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA., Packer R; Brain Tumor Institute, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA., Mueller S; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.; Department of Neurology, Neurosurgery and Pediatrics, University of California San Francisco, San Francisco, CA, USA., Nazarian J; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. javad.nazarian@kispi.uzh.ch.
Source: NPJ precision oncology [NPJ Precis Oncol] 2025 Jul 01; Vol. 9 (1), pp. 209. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Dual treatment with Val-083 and AZD1775 shows potent anti-tumor activity in diffuse midline glioma models.
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  Data: <searchLink fieldCode="AU" term="%22Subramaniam+B%22">Subramaniam B</searchLink>; Brain Tumor Institute, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Roy+D%22">Roy D</searchLink>; Brain Tumor Institute, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Woldegerima+A%22">Woldegerima A</searchLink>; Brain Tumor Institute, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Chong+WC%22">Chong WC</searchLink>; Brain Tumor Institute, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Przystal+JM%22">Przystal JM</searchLink>; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Laternser+S%22">Laternser S</searchLink>; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kritzer+B%22">Kritzer B</searchLink>; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rangnath+S%22">Rangnath S</searchLink>; University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Knowles+T%22">Knowles T</searchLink>; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yadavilli+S%22">Yadavilli S</searchLink>; Brain Tumor Institute, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Packer+R%22">Packer R</searchLink>; Brain Tumor Institute, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Mueller+S%22">Mueller S</searchLink>; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.; Department of Neurology, Neurosurgery and Pediatrics, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nazarian+J%22">Nazarian J</searchLink>; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. javad.nazarian@kispi.uzh.ch.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101708166 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2397-768X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222397768X%22">2397768X </searchLink><i>NLM ISO Abbreviation: </i>NPJ Precis Oncol <i>Subsets: </i>PubMed not MEDLINE
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