Orthosteric STING inhibition elucidates molecular correction of SAVI STING.
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| Title: | Orthosteric STING inhibition elucidates molecular correction of SAVI STING. |
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| Authors: | Xie T; Drug Discovery Analytical, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA. tao.xie@bms.com., Ruzanov M; Structural Biology, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Critton D; Structural Biology, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Merselis L; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA., Naglich J; Mechanistic Pharmacology, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Sack JS; Structural Biology, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Zhang P; Protein Science, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Xie C; Mechanistic Pharmacology, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Tredup J; Protein Science, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Stine LB; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA., Messier C; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA., Hope DL; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA., Caceres-Cortes J; Drug Discovery Analytical, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Mueller L; Drug Discovery Analytical, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Dyckman AJ; Immunology Chemistry, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Newitt JA; Protein Science, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Choudhury A; Biocon-Bristol Myers Squibb Research and Development Center, Biocon Park, Plot No. 2 & 3, Bommasandra Phase IV, Jigani Link Road, Bangalore, 560099, India., Wilson SC; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA. scwilson@gmail.com. |
| Source: | Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5695. Date of Electronic Publication: 2025 Jul 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-60632-5 |
