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Orthosteric STING inhibition elucidates molecular correction of SAVI STING.

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Title: Orthosteric STING inhibition elucidates molecular correction of SAVI STING.
Authors: Xie T; Drug Discovery Analytical, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA. tao.xie@bms.com., Ruzanov M; Structural Biology, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Critton D; Structural Biology, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Merselis L; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA., Naglich J; Mechanistic Pharmacology, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Sack JS; Structural Biology, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Zhang P; Protein Science, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Xie C; Mechanistic Pharmacology, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Tredup J; Protein Science, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Stine LB; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA., Messier C; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA., Hope DL; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA., Caceres-Cortes J; Drug Discovery Analytical, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Mueller L; Drug Discovery Analytical, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Dyckman AJ; Immunology Chemistry, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Newitt JA; Protein Science, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA., Choudhury A; Biocon-Bristol Myers Squibb Research and Development Center, Biocon Park, Plot No. 2 & 3, Bommasandra Phase IV, Jigani Link Road, Bangalore, 560099, India., Wilson SC; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA. scwilson@gmail.com.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5695. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Orthosteric STING inhibition elucidates molecular correction of SAVI STING.
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  Data: <searchLink fieldCode="AU" term="%22Xie+T%22">Xie T</searchLink>; Drug Discovery Analytical, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA. tao.xie@bms.com.<br /><searchLink fieldCode="AU" term="%22Ruzanov+M%22">Ruzanov M</searchLink>; Structural Biology, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA.<br /><searchLink fieldCode="AU" term="%22Critton+D%22">Critton D</searchLink>; Structural Biology, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA.<br /><searchLink fieldCode="AU" term="%22Merselis+L%22">Merselis L</searchLink>; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA.<br /><searchLink fieldCode="AU" term="%22Naglich+J%22">Naglich J</searchLink>; Mechanistic Pharmacology, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA.<br /><searchLink fieldCode="AU" term="%22Sack+JS%22">Sack JS</searchLink>; Structural Biology, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; Protein Science, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA.<br /><searchLink fieldCode="AU" term="%22Xie+C%22">Xie C</searchLink>; Mechanistic Pharmacology, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA.<br /><searchLink fieldCode="AU" term="%22Tredup+J%22">Tredup J</searchLink>; Protein Science, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA.<br /><searchLink fieldCode="AU" term="%22Stine+LB%22">Stine LB</searchLink>; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA.<br /><searchLink fieldCode="AU" term="%22Messier+C%22">Messier C</searchLink>; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA.<br /><searchLink fieldCode="AU" term="%22Hope+DL%22">Hope DL</searchLink>; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA.<br /><searchLink fieldCode="AU" term="%22Caceres-Cortes+J%22">Caceres-Cortes J</searchLink>; Drug Discovery Analytical, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA.<br /><searchLink fieldCode="AU" term="%22Mueller+L%22">Mueller L</searchLink>; Drug Discovery Analytical, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA.<br /><searchLink fieldCode="AU" term="%22Dyckman+AJ%22">Dyckman AJ</searchLink>; Immunology Chemistry, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA.<br /><searchLink fieldCode="AU" term="%22Newitt+JA%22">Newitt JA</searchLink>; Protein Science, Lead Discovery and Optimization, Discovery & Development Sciences, Bristol Myers Squibb, Lawrenceville, NJ, 08648, USA.<br /><searchLink fieldCode="AU" term="%22Choudhury+A%22">Choudhury A</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Biocon Park, Plot No. 2 & 3, Bommasandra Phase IV, Jigani Link Road, Bangalore, 560099, India.<br /><searchLink fieldCode="AU" term="%22Wilson+SC%22">Wilson SC</searchLink>; Discovery Immunology, Bristol Myers Squibb, 250 Water St, Cambridge, MA, 02141, USA. scwilson@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5695. <i>Date of Electronic Publication: </i>2025 Jul 01.
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