Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy.
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| Title: | Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy. |
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| Authors: | Zborowsky S; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France., Seurat J; Institut de Biologie, Ecole Normale Supérieure, Paris, France.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA., Balacheff Q; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France.; CHU Felix Guyon, Service des maladies respiratoires, Saint Denis, France., Ecomard S; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France.; DGA, Paris, France.; Sorbonne Université, Collège Doctoral, Paris, France., Mulet C; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France., Minh CNN; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France.; Sorbonne Université, Collège Doctoral, Paris, France., Titécat M; Université de Lille, INSERM, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, Lille, France., Evrard E; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France., Rodriguez-Gonzalez RA; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.; Interdisciplinary Graduate Program in Quantitative Biosciences, Georgia Institute of Technology, Atlanta, GA, USA., Marchi J; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.; Department of Biology, University of Maryland, College Park, MD, USA., Weitz JS; Institut de Biologie, Ecole Normale Supérieure, Paris, France. jsweitz@umd.edu.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. jsweitz@umd.edu.; Department of Biology, University of Maryland, College Park, MD, USA. jsweitz@umd.edu.; University of Maryland Institute for Health Computing, North Bethesda, MD, USA. jsweitz@umd.edu., Debarbieux L; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France. laurent.debarbieux@pasteur.fr. |
| Source: | Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5725. Date of Electronic Publication: 2025 Jul 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-61268-1 |
