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Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy.

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Title: Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy.
Authors: Zborowsky S; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France., Seurat J; Institut de Biologie, Ecole Normale Supérieure, Paris, France.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA., Balacheff Q; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France.; CHU Felix Guyon, Service des maladies respiratoires, Saint Denis, France., Ecomard S; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France.; DGA, Paris, France.; Sorbonne Université, Collège Doctoral, Paris, France., Mulet C; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France., Minh CNN; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France.; Sorbonne Université, Collège Doctoral, Paris, France., Titécat M; Université de Lille, INSERM, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, Lille, France., Evrard E; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France., Rodriguez-Gonzalez RA; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.; Interdisciplinary Graduate Program in Quantitative Biosciences, Georgia Institute of Technology, Atlanta, GA, USA., Marchi J; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.; Department of Biology, University of Maryland, College Park, MD, USA., Weitz JS; Institut de Biologie, Ecole Normale Supérieure, Paris, France. jsweitz@umd.edu.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. jsweitz@umd.edu.; Department of Biology, University of Maryland, College Park, MD, USA. jsweitz@umd.edu.; University of Maryland Institute for Health Computing, North Bethesda, MD, USA. jsweitz@umd.edu., Debarbieux L; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France. laurent.debarbieux@pasteur.fr.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5725. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy.
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  Data: <searchLink fieldCode="AU" term="%22Zborowsky+S%22">Zborowsky S</searchLink>; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France.<br /><searchLink fieldCode="AU" term="%22Seurat+J%22">Seurat J</searchLink>; Institut de Biologie, Ecole Normale Supérieure, Paris, France.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Balacheff+Q%22">Balacheff Q</searchLink>; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France.; CHU Felix Guyon, Service des maladies respiratoires, Saint Denis, France.<br /><searchLink fieldCode="AU" term="%22Ecomard+S%22">Ecomard S</searchLink>; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France.; DGA, Paris, France.; Sorbonne Université, Collège Doctoral, Paris, France.<br /><searchLink fieldCode="AU" term="%22Mulet+C%22">Mulet C</searchLink>; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France.<br /><searchLink fieldCode="AU" term="%22Minh+CNN%22">Minh CNN</searchLink>; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France.; Sorbonne Université, Collège Doctoral, Paris, France.<br /><searchLink fieldCode="AU" term="%22Titécat+M%22">Titécat M</searchLink>; Université de Lille, INSERM, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, Lille, France.<br /><searchLink fieldCode="AU" term="%22Evrard+E%22">Evrard E</searchLink>; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Gonzalez+RA%22">Rodriguez-Gonzalez RA</searchLink>; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.; Interdisciplinary Graduate Program in Quantitative Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Marchi+J%22">Marchi J</searchLink>; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.; Department of Biology, University of Maryland, College Park, MD, USA.<br /><searchLink fieldCode="AU" term="%22Weitz+JS%22">Weitz JS</searchLink>; Institut de Biologie, Ecole Normale Supérieure, Paris, France. jsweitz@umd.edu.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. jsweitz@umd.edu.; Department of Biology, University of Maryland, College Park, MD, USA. jsweitz@umd.edu.; University of Maryland Institute for Health Computing, North Bethesda, MD, USA. jsweitz@umd.edu.<br /><searchLink fieldCode="AU" term="%22Debarbieux+L%22">Debarbieux L</searchLink>; Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris, France. laurent.debarbieux@pasteur.fr.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5725. <i>Date of Electronic Publication: </i>2025 Jul 01.
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