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The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement.

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Title: The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement.
Authors: Perryman L; Syntara, Frenchs Forest, NSW, Australia., Findlay A; Syntara, Frenchs Forest, NSW, Australia., Baskar J; Syntara, Frenchs Forest, NSW, Australia., Charlton B; Syntara, Frenchs Forest, NSW, Australia., Foot J; Syntara, Frenchs Forest, NSW, Australia., Hamilton R; Syntara, Frenchs Forest, NSW, Australia., Hamprecht D; Syntara, Frenchs Forest, NSW, Australia., Joshi A; Syntara, Frenchs Forest, NSW, Australia., Stolp J; Syntara, Frenchs Forest, NSW, Australia., Turner C; Syntara, Frenchs Forest, NSW, Australia., Zahoor A; Syntara, Frenchs Forest, NSW, Australia., Zhou W; Syntara, Frenchs Forest, NSW, Australia., López B; Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA , Pamplona, Spain.; CIBERCV, Carlos II Institute of Health, Madrid, Spain., Ravassa S; Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA , Pamplona, Spain.; CIBERCV, Carlos II Institute of Health, Madrid, Spain., González A; Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA , Pamplona, Spain.; CIBERCV, Carlos II Institute of Health, Madrid, Spain.; Department of Cardiology and Cardiac Surgery, Clínica Universidad de Navarra, Pamplona, Spain., Jarolimek W; Syntara, Frenchs Forest, NSW, Australia. Wolfgang.Jarolimek@Syntaratx.com.au.
Source: Scientific reports [Sci Rep] 2025 Jul 02; Vol. 15 (1), pp. 22653. Date of Electronic Publication: 2025 Jul 02.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement.
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  Data: <searchLink fieldCode="AU" term="%22Perryman+L%22">Perryman L</searchLink>; Syntara, Frenchs Forest, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Findlay+A%22">Findlay A</searchLink>; Syntara, Frenchs Forest, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Baskar+J%22">Baskar J</searchLink>; Syntara, Frenchs Forest, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Charlton+B%22">Charlton B</searchLink>; Syntara, Frenchs Forest, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Foot+J%22">Foot J</searchLink>; Syntara, Frenchs Forest, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Hamilton+R%22">Hamilton R</searchLink>; Syntara, Frenchs Forest, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Hamprecht+D%22">Hamprecht D</searchLink>; Syntara, Frenchs Forest, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Joshi+A%22">Joshi A</searchLink>; Syntara, Frenchs Forest, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Stolp+J%22">Stolp J</searchLink>; Syntara, Frenchs Forest, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Turner+C%22">Turner C</searchLink>; Syntara, Frenchs Forest, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Zahoor+A%22">Zahoor A</searchLink>; Syntara, Frenchs Forest, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Syntara, Frenchs Forest, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22López+B%22">López B</searchLink>; Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA , Pamplona, Spain.; CIBERCV, Carlos II Institute of Health, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ravassa+S%22">Ravassa S</searchLink>; Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA , Pamplona, Spain.; CIBERCV, Carlos II Institute of Health, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22González+A%22">González A</searchLink>; Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA , Pamplona, Spain.; CIBERCV, Carlos II Institute of Health, Madrid, Spain.; Department of Cardiology and Cardiac Surgery, Clínica Universidad de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Jarolimek+W%22">Jarolimek W</searchLink>; Syntara, Frenchs Forest, NSW, Australia. Wolfgang.Jarolimek@Syntaratx.com.au.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2025 Jul 02; Vol. 15 (1), pp. 22653. <i>Date of Electronic Publication: </i>2025 Jul 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41598-025-06312-2
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              Text: 2025 Jul 02
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