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Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons.

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Title: Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons.
Authors: Edmonds KK; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Wilkinson ME; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Strebinger D; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Chen H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Lash B; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Schaefer CC; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Zhu S; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Liu D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Zilberzwige-Tal S; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Ladha A; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Walsh ML; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Frangieh CJ; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Vaz Reay NA; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Macrae RK; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Wang X; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT, Cambridge, MA, 02142, USA., Zhang F; Howard Hughes Medical Institute, Cambridge, MA, USA. zhang@broadinstitute.org.; Yang Tan Collective, Cambridge, MA, USA. zhang@broadinstitute.org.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA. zhang@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. zhang@broadinstitute.org.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA. zhang@broadinstitute.org.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. zhang@broadinstitute.org.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. zhang@broadinstitute.org.
Source: Nature communications [Nat Commun] 2025 Jul 02; Vol. 16 (1), pp. 6079. Date of Electronic Publication: 2025 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons.
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  Data: <searchLink fieldCode="AU" term="%22Edmonds+KK%22">Edmonds KK</searchLink>; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wilkinson+ME%22">Wilkinson ME</searchLink>; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; 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Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schaefer+CC%22">Schaefer CC</searchLink>; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; 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Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ladha+A%22">Ladha A</searchLink>; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Walsh+ML%22">Walsh ML</searchLink>; 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Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vaz+Reay+NA%22">Vaz Reay NA</searchLink>; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Macrae+RK%22">Macrae RK</searchLink>; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; Howard Hughes Medical Institute, Cambridge, MA, USA. zhang@broadinstitute.org.; Yang Tan Collective, Cambridge, MA, USA. zhang@broadinstitute.org.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA. zhang@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. zhang@broadinstitute.org.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA. zhang@broadinstitute.org.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. zhang@broadinstitute.org.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. zhang@broadinstitute.org.
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