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Irradiation of prostate cancer alters circulating small extracellular vesicle functions.

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Title: Irradiation of prostate cancer alters circulating small extracellular vesicle functions.
Authors: Sayeed A; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street Suite 506, Philadelphia, PA, 19107, USA.; Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Baruch S. Blumberg Institute, Doylestown, PA, USA., Garcia V; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street Suite 506, Philadelphia, PA, 19107, USA.; Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA., Verrillo CE; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street Suite 506, Philadelphia, PA, 19107, USA.; Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA., DeRita RM; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street Suite 506, Philadelphia, PA, 19107, USA.; Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA., Hossain MN; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street Suite 506, Philadelphia, PA, 19107, USA.; Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA., Krishn SR; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street Suite 506, Philadelphia, PA, 19107, USA.; Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA., Sey S; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street Suite 506, Philadelphia, PA, 19107, USA.; Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA., Shields CD; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street Suite 506, Philadelphia, PA, 19107, USA.; Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA., Altieri AD; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street Suite 506, Philadelphia, PA, 19107, USA.; Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA., Liu Q; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA., Sossey-Alaoui K; Department of Medicine, School of Medicine MetroHealth Medical Center Rammelkamp Center for Research, Case Western Reserve University, Cleveland, OH, USA., Kelly WK; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street Suite 506, Philadelphia, PA, 19107, USA.; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA., Languino LR; Prostate Cancer Discovery and Development Program, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street Suite 506, Philadelphia, PA, 19107, USA. lucia.languino@jefferson.edu.; Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA. lucia.languino@jefferson.edu.
Source: Scientific reports [Sci Rep] 2025 Jul 02; Vol. 15 (1), pp. 23217. Date of Electronic Publication: 2025 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2045-2322
DOI:10.1038/s41598-025-03329-5