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Gut microbiome compositional and functional features associate with Alzheimer's disease pathology.

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Title: Gut microbiome compositional and functional features associate with Alzheimer's disease pathology.
Authors: Kang JW; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Khatib LA; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.; Neurosciences Graduate Program, University of California, San Diego, La Jolla, California, USA., Heston MB; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Dilmore AH; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA., Labus JS; Integrative Biostatistics and Bioinformatics Core (IBBC) at the Goodman-Luskin Microbiome Center, Los Angeles, California, USA.; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California, USA.; UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Deming Y; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Schimmel L; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA., Blach C; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA., McDonald D; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA., Gonzalez A; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA., Bryant M; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA., Ulland TK; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Johnson SC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Asthana S; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Carlsson CM; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Chin NA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden., Zetterberg H; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China., Rey FE; Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Kaddurah-Daouk R; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.; Duke Institute of Brain Sciences, Duke University, Durham, North Carolina, USA.; Department of Medicine, Duke University, Durham, North Carolina, USA., Knight R; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.; Center for Microbiome Innovation, Joan and Irwin Jacobs School of Engineering, University of California, San Diego, La Jolla, California, USA.; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California, USA.; Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, California, USA.; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, California, USA., Bendlin BB; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Corporate Authors: Alzheimer Gut Microbiome Project Consortium; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Jul; Vol. 21 (7), pp. e70417.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Gut microbiome compositional and functional features associate with Alzheimer's disease pathology.
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  Data: <searchLink fieldCode="AU" term="%22Kang+JW%22">Kang JW</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Khatib+LA%22">Khatib LA</searchLink>; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.; Neurosciences Graduate Program, University of California, San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Heston+MB%22">Heston MB</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Dilmore+AH%22">Dilmore AH</searchLink>; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Labus+JS%22">Labus JS</searchLink>; Integrative Biostatistics and Bioinformatics Core (IBBC) at the Goodman-Luskin Microbiome Center, Los Angeles, California, USA.; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California, USA.; UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Deming+Y%22">Deming Y</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Schimmel+L%22">Schimmel L</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Blach+C%22">Blach C</searchLink>; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22McDonald+D%22">McDonald D</searchLink>; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+A%22">Gonzalez A</searchLink>; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Bryant+M%22">Bryant M</searchLink>; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Ulland+TK%22">Ulland TK</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+SC%22">Johnson SC</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Asthana+S%22">Asthana S</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Carlsson+CM%22">Carlsson CM</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Chin+NA%22">Chin NA</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Rey+FE%22">Rey FE</searchLink>; Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Kaddurah-Daouk+R%22">Kaddurah-Daouk R</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.; Duke Institute of Brain Sciences, Duke University, Durham, North Carolina, USA.; Department of Medicine, Duke University, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Knight+R%22">Knight R</searchLink>; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.; Center for Microbiome Innovation, Joan and Irwin Jacobs School of Engineering, University of California, San Diego, La Jolla, California, USA.; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California, USA.; Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, California, USA.; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Bendlin+BB%22">Bendlin BB</searchLink>; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
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  Data: <searchLink fieldCode="CA" term="%22Alzheimer+Gut+Microbiome+Project+Consortium%22">Alzheimer Gut Microbiome Project Consortium</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2025 Jul; Vol. 21 (7), pp. e70417.
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