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An orally bioavailable BRD4 inhibitor disrupts expansion of a pathogenic epithelial-mesenchymal niche in bleomycin-induced fibrosis.

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Title: An orally bioavailable BRD4 inhibitor disrupts expansion of a pathogenic epithelial-mesenchymal niche in bleomycin-induced fibrosis.
Authors: Skibba M; Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA., Ma Z; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA., Wilson CL; Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA., Liu Z; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA., Chen H; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA., Tian B; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA., Harr TJ; Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA., Schnapp LM; Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA., Sandbo N; Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA., Zhou J; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA., Brasier AR; Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA. abrasier@wisc.edu.; Institute for Clinical and Translational Research, University of Wisconsin Madison, Madison, WI, USA. abrasier@wisc.edu.
Source: Respiratory research [Respir Res] 2025 Jul 02; Vol. 26 (1), pp. 221. Date of Electronic Publication: 2025 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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        Value: 10.1186/s12931-025-03306-6
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              Text: 2025 Jul 02
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