Recent Antiretroviral Therapy Initiation Is Associated With Increased Mortality Risk in HIV-associated Cryptococcal Meningitis: An Analysis of Clinical Trial Data From Africa.

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Title: Recent Antiretroviral Therapy Initiation Is Associated With Increased Mortality Risk in HIV-associated Cryptococcal Meningitis: An Analysis of Clinical Trial Data From Africa.
Authors: Moyo M; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi.; Department of Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi., Lawrence DS; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Botswana-Harvard Health Partnership, Gaborone, Botswana., Jafali J; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi., Molloy SF; Centre for Global Health, Institute of Infection and Immunity, St George's University of London, London, United Kingdom., Kumwenda J; Department of Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi., Kanyama C; University of North Carolina Project, Kamuzu Central Hospital, Lilongwe, Malawi., Hosseinipour MC; University of North Carolina Project, Kamuzu Central Hospital, Lilongwe, Malawi.; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill North Carolina  USA., Ndhlovu CE; Department of Internal Medicine, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Mosepele M; Botswana-Harvard Health Partnership, Gaborone, Botswana.; Department of Internal Medicine, Faculty of Medicine, University of Botswana, Gaborone, Botswana., Meya DB; Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda., Rhein J; Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.; Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Boulware DR; Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Muzoora C; Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda., Gupta RK; Institute for Global Health, University College London, London, United Kingdom., Samuels THA; Institute for Global Health, University College London, London, United Kingdom., Youssouf N; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Botswana-Harvard Health Partnership, Gaborone, Botswana., Chammard TB; Necker Pasteur Center for Infectious Diseases and Tropical Medicine, Hôpital Necker Enfants malades, AP-HP, IHU Imagine, Université de Paris, Paris, France.; Molecular Mycology Unit and National Reference Centre for Invasive Mycoses, UMR2000, CNRS, Institut Pasteur, Paris, France., Lortholary O; Necker Pasteur Center for Infectious Diseases and Tropical Medicine, Hôpital Necker Enfants malades, AP-HP, IHU Imagine, Université de Paris, Paris, France.; Molecular Mycology Unit and National Reference Centre for Invasive Mycoses, UMR2000, CNRS, Institut Pasteur, Paris, France., Schutz C; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Medicine, University of Cape Town, Cape Town, South Africa., Meintjes G; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Medicine, University of Cape Town, Cape Town, South Africa.; Blizard Institute, Queen Mary University of London, London, United Kingdom., Mwandumba HC; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi.; Department of Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Harrison TS; Centre for Global Health, Institute of Infection and Immunity, St George's University of London, London, United Kingdom., Jarvis JN; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Botswana-Harvard Health Partnership, Gaborone, Botswana.
Source: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2025 Aug 01; Vol. 81 (1), pp. 75-83.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE
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  Data: Recent Antiretroviral Therapy Initiation Is Associated With Increased Mortality Risk in HIV-associated Cryptococcal Meningitis: An Analysis of Clinical Trial Data From Africa.
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  Data: <searchLink fieldCode="AU" term="%22Moyo+M%22">Moyo M</searchLink>; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi.; Department of Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Lawrence+DS%22">Lawrence DS</searchLink>; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Botswana-Harvard Health Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Jafali+J%22">Jafali J</searchLink>; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Molloy+SF%22">Molloy SF</searchLink>; Centre for Global Health, Institute of Infection and Immunity, St George's University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kumwenda+J%22">Kumwenda J</searchLink>; Department of Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Kanyama+C%22">Kanyama C</searchLink>; University of North Carolina Project, Kamuzu Central Hospital, Lilongwe, Malawi.<br /><searchLink fieldCode="AU" term="%22Hosseinipour+MC%22">Hosseinipour MC</searchLink>; University of North Carolina Project, Kamuzu Central Hospital, Lilongwe, Malawi.; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill North Carolina  USA.<br /><searchLink fieldCode="AU" term="%22Ndhlovu+CE%22">Ndhlovu CE</searchLink>; Department of Internal Medicine, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Mosepele+M%22">Mosepele M</searchLink>; Botswana-Harvard Health Partnership, Gaborone, Botswana.; Department of Internal Medicine, Faculty of Medicine, University of Botswana, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Meya+DB%22">Meya DB</searchLink>; Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Rhein+J%22">Rhein J</searchLink>; Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.; Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Boulware+DR%22">Boulware DR</searchLink>; Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Muzoora+C%22">Muzoora C</searchLink>; Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Gupta+RK%22">Gupta RK</searchLink>; Institute for Global Health, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Samuels+THA%22">Samuels THA</searchLink>; Institute for Global Health, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Youssouf+N%22">Youssouf N</searchLink>; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Botswana-Harvard Health Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Chammard+TB%22">Chammard TB</searchLink>; Necker Pasteur Center for Infectious Diseases and Tropical Medicine, Hôpital Necker Enfants malades, AP-HP, IHU Imagine, Université de Paris, Paris, France.; Molecular Mycology Unit and National Reference Centre for Invasive Mycoses, UMR2000, CNRS, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22Lortholary+O%22">Lortholary O</searchLink>; Necker Pasteur Center for Infectious Diseases and Tropical Medicine, Hôpital Necker Enfants malades, AP-HP, IHU Imagine, Université de Paris, Paris, France.; Molecular Mycology Unit and National Reference Centre for Invasive Mycoses, UMR2000, CNRS, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22Schutz+C%22">Schutz C</searchLink>; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Medicine, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Meintjes+G%22">Meintjes G</searchLink>; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Medicine, University of Cape Town, Cape Town, South Africa.; Blizard Institute, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mwandumba+HC%22">Mwandumba HC</searchLink>; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi.; Department of Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Harrison+TS%22">Harrison TS</searchLink>; Centre for Global Health, Institute of Infection and Immunity, St George's University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Jarvis+JN%22">Jarvis JN</searchLink>; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.; Botswana-Harvard Health Partnership, Gaborone, Botswana.
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