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Chlorinated biscoumarins inhibit chikungunya virus replication in cell-based and animal models.

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Title: Chlorinated biscoumarins inhibit chikungunya virus replication in cell-based and animal models.
Authors: Orji CN; Center of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Medical Science Program, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Loeanurit N; Center of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Pham VC; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand., Phan TH; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand., Hengphasatporn K; Center for Computational Sciences, University of Tsukuba, Ibaraki, Japan., Shigeta Y; Center for Computational Sciences, University of Tsukuba, Ibaraki, Japan., Putri AD; Center of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences, Jakarta, Indonesia., Lello LS; Institute of Bioengineering, University of Tartu, Tartu, Estonia., Merits A; Institute of Bioengineering, University of Tartu, Tartu, Estonia., Wacharachaisurapol N; Department of Pharmacology, Center of Excellence in Clinical Pharmacokinetics and Pharmacogenomics, Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Eiamart W; Chula Pharmacokinetic Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Wittayalertpanya S; Department of Pharmacology, Center of Excellence in Clinical Pharmacokinetics and Pharmacogenomics, Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Chula Pharmacokinetic Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Khotavivattana T; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand., Chavasiri W; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand., Boonyasuppayakorn S; Center of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Source: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2529889. Date of Electronic Publication: 2025 Jul 28.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chlorinated biscoumarins inhibit chikungunya virus replication in cell-based and animal models.
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  Data: <searchLink fieldCode="AU" term="%22Orji+CN%22">Orji CN</searchLink>; Center of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Medical Science Program, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Loeanurit+N%22">Loeanurit N</searchLink>; Center of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Pham+VC%22">Pham VC</searchLink>; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Phan+TH%22">Phan TH</searchLink>; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Hengphasatporn+K%22">Hengphasatporn K</searchLink>; Center for Computational Sciences, University of Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Shigeta+Y%22">Shigeta Y</searchLink>; Center for Computational Sciences, University of Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Putri+AD%22">Putri AD</searchLink>; Center of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences, Jakarta, Indonesia.<br /><searchLink fieldCode="AU" term="%22Lello+LS%22">Lello LS</searchLink>; Institute of Bioengineering, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Merits+A%22">Merits A</searchLink>; Institute of Bioengineering, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Wacharachaisurapol+N%22">Wacharachaisurapol N</searchLink>; Department of Pharmacology, Center of Excellence in Clinical Pharmacokinetics and Pharmacogenomics, Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Eiamart+W%22">Eiamart W</searchLink>; Chula Pharmacokinetic Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Wittayalertpanya+S%22">Wittayalertpanya S</searchLink>; Department of Pharmacology, Center of Excellence in Clinical Pharmacokinetics and Pharmacogenomics, Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Chula Pharmacokinetic Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Khotavivattana+T%22">Khotavivattana T</searchLink>; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Chavasiri+W%22">Chavasiri W</searchLink>; Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Boonyasuppayakorn+S%22">Boonyasuppayakorn S</searchLink>; Center of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
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  Data: <searchLink fieldCode="JN" term="%22101594885%22">Emerging microbes & infections</searchLink> [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2529889. <i>Date of Electronic Publication: </i>2025 Jul 28.
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              Text: 2025 Dec
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