Design, synthesis, anticancer activity, and in silico computational studies of new imidazolone-based derivatives with potential multi-target kinase inhibitory activity.
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| Title: | Design, synthesis, anticancer activity, and in silico computational studies of new imidazolone-based derivatives with potential multi-target kinase inhibitory activity. |
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| Authors: | Ahmed NS; Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), El Bohouth St., Dokki, Cairo 12622, Egypt. Electronic address: nesreen69eg@yahoo.com., Abd El-Karim SS; Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), El Bohouth St., Dokki, Cairo 12622, Egypt. Electronic address: ssabdelkarim@gmail.com., Anwar MM; Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), El Bohouth St., Dokki, Cairo 12622, Egypt., Mohamed NA; Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), El Bohouth St., Dokki, Cairo 12622, Egypt., El-Sayed AF; Microbial Genetics Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt., Khalifa NM; Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), El Bohouth St., Dokki, Cairo 12622, Egypt. |
| Source: | Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Nov 01; Vol. 129, pp. 118292. Date of Electronic Publication: 2025 Jun 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40609134 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Design, synthesis, anticancer activity, and in silico computational studies of new imidazolone-based derivatives with potential multi-target kinase inhibitory activity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ahmed+NS%22">Ahmed NS</searchLink>; Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), El Bohouth St., Dokki, Cairo 12622, Egypt. Electronic address: nesreen69eg@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Abd+El-Karim+SS%22">Abd El-Karim SS</searchLink>; Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), El Bohouth St., Dokki, Cairo 12622, Egypt. Electronic address: ssabdelkarim@gmail.com.<br /><searchLink fieldCode="AU" term="%22Anwar+MM%22">Anwar MM</searchLink>; Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), El Bohouth St., Dokki, Cairo 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohamed+NA%22">Mohamed NA</searchLink>; Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), El Bohouth St., Dokki, Cairo 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Sayed+AF%22">El-Sayed AF</searchLink>; Microbial Genetics Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Khalifa+NM%22">Khalifa NM</searchLink>; Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), El Bohouth St., Dokki, Cairo 12622, Egypt. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229413298%22">Bioorganic & medicinal chemistry</searchLink> [Bioorg Med Chem] 2025 Nov 01; Vol. 129, pp. 118292. <i>Date of Electronic Publication: </i>2025 Jun 25. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9413298 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3391 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209680896%22">09680896 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40609134 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.bmc.2025.118292 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 118292 Titles: – TitleFull: Design, synthesis, anticancer activity, and in silico computational studies of new imidazolone-based derivatives with potential multi-target kinase inhibitory activity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ahmed NS – PersonEntity: Name: NameFull: Abd El-Karim SS – PersonEntity: Name: NameFull: Anwar MM – PersonEntity: Name: NameFull: Mohamed NA – PersonEntity: Name: NameFull: El-Sayed AF – PersonEntity: Name: NameFull: Khalifa NM IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: 2025 Nov 01 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1464-3391 Numbering: – Type: volume Value: 129 Titles: – TitleFull: Bioorganic & medicinal chemistry Type: main |
| ResultId | 1 |
