Impact of doxycycline pre-exposure prophylaxis (doxyPrEP) for sexually transmitted infections on the microbiome of men who have sex with men on HIV PrEP.

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Title: Impact of doxycycline pre-exposure prophylaxis (doxyPrEP) for sexually transmitted infections on the microbiome of men who have sex with men on HIV PrEP.
Authors: Knodel S; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB, Canada., Main L; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH, USA., DeLeon M; Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada., Lamont A; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada., Edward J; BC Centre for Disease Control, Vancouver, BC, Canada.; Nova Scotia Health, Halifax, NS, Canada., Gupta AK; BC Centre for Disease Control, Vancouver, BC, Canada., Noel-Romas L; Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada., Mohammed S; BC Centre for Disease Control, Vancouver, BC, Canada.; BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada., Tattersall T; BC Centre for Disease Control, Vancouver, BC, Canada., Wong J; BC Centre for Disease Control, Vancouver, BC, Canada.; University of British Columbia, Vancouver, BC, Canada., Hull M; BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.; University of British Columbia, Vancouver, BC, Canada.; CIHR Canadian HIV Trials Network, Montreal, QC, Canada., Grennan T; BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. troy.grennan@bccdc.ca.; University of British Columbia, Vancouver, BC, Canada. troy.grennan@bccdc.ca.; CIHR Canadian HIV Trials Network, Montreal, QC, Canada. troy.grennan@bccdc.ca., Burgener AD; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. adam.burgener@cwru.edu.; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB, Canada. adam.burgener@cwru.edu.; Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden. adam.burgener@cwru.edu.
Source: Nature communications [Nat Commun] 2025 Jul 03; Vol. 16 (1), pp. 6143. Date of Electronic Publication: 2025 Jul 03.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Impact of doxycycline pre-exposure prophylaxis (doxyPrEP) for sexually transmitted infections on the microbiome of men who have sex with men on HIV PrEP.
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