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Insights into ancestral diversity in Parkinson's disease risk: a comparative assessment of polygenic risk scores.

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Title: Insights into ancestral diversity in Parkinson's disease risk: a comparative assessment of polygenic risk scores.
Authors: Saffie-Awad P; Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Centro de Trastornos del Movimiento (CETRAM), Santiago, Chile.; Clínica Santa María, Santiago, Chile., Grant SM; Centre for Alzheimer's and Related Dementias. National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Makarious MB; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK., Elsayed I; Faculty of Pharmacy, University of Gezira, Wadmadani, Sudan., Sanyaolu AO; Department of Anatomy, College of Medicine, University of Lagos, Lagos, Nigeria., Crea PW; Centre for Alzheimer's and Related Dementias. National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Schumacher Schuh AF; Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Levine KS; Centre for Alzheimer's and Related Dementias. National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA., Vitale D; Centre for Alzheimer's and Related Dementias. National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA., Koretsky MJ; Centre for Alzheimer's and Related Dementias. National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Kim J; Centre for Alzheimer's and Related Dementias. National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Peixoto Leal T; Genomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA., Periñán MT; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Dey S; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Noyce AJ; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Reyes-Palomares A; Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Málaga, Málaga, Spain., Rodriguez-Losada N; Faculty of Education Sciences, University of Málaga, Málaga, Spain., Foo JN; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.; Laboratory of Neurogenetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Mohamed W; Neuroscience Unit, Clinical Pharmacology Dept, Menoufia Medical School, Shebeen El-Kom, Egypt., Heilbron K; 23andMe Inc., Sunnyvale, CA, USA., Norcliffe-Kaufmann L; 23andMe Inc., Sunnyvale, CA, USA., Rizig M; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Okubadejo N; Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria., Nalls MA; Centre for Alzheimer's and Related Dementias. National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA., Blauwendraat C; Centre for Alzheimer's and Related Dementias. National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Singleton A; Centre for Alzheimer's and Related Dementias. National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Leonard H; Centre for Alzheimer's and Related Dementias. National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Mata IF; Genomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA., Bandres-Ciga S; Centre for Alzheimer's and Related Dementias. National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. sarabandres@gmail.com.
Corporate Authors: 23andMe Research Team, Global Parkinson’s Genetics Program (GP2)
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2025 Jul 03; Vol. 11 (1), pp. 201. Date of Electronic Publication: 2025 Jul 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2373-8057
DOI:10.1038/s41531-025-00967-4