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Discovery of the Clinical Candidate S-892216: A Second-Generation of SARS-CoV-2 3CL Protease Inhibitor for Treating COVID-19.

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Title: Discovery of the Clinical Candidate S-892216: A Second-Generation of SARS-CoV-2 3CL Protease Inhibitor for Treating COVID-19.
Authors: Unoh Y; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Hirai K; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Uehara S; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Kawashima S; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Nobori H; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Sato J; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Shibayama H; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Hori A; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Nakahara K; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Kurahashi K; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Takamatsu M; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Yamamoto S; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Zhang Q; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Tanimura M; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Dodo R; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Maruyama Y; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Sawa H; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo 001-0021, Japan.; International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.; One Health Research Center, Hokkaido University, Sapporo 060-0818, Japan.; Global Virus Network, 12901 Bruce B. Downs Blvd. MDC02, Tampa, Florida 33612, United States., Watari R; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Miyano T; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Kato T; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Sato T; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan., Tachibana Y; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21099-21119. Date of Electronic Publication: 2025 Jul 05.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: Discovery of the Clinical Candidate S-892216: A Second-Generation of SARS-CoV-2 3CL Protease Inhibitor for Treating COVID-19.
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  Data: <searchLink fieldCode="AU" term="%22Unoh+Y%22">Unoh Y</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Hirai+K%22">Hirai K</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Uehara+S%22">Uehara S</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Kawashima+S%22">Kawashima S</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Nobori+H%22">Nobori H</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+J%22">Sato J</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Shibayama+H%22">Shibayama H</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Hori+A%22">Hori A</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Nakahara+K%22">Nakahara K</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Kurahashi+K%22">Kurahashi K</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Takamatsu+M%22">Takamatsu M</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+S%22">Yamamoto S</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Tanimura+M%22">Tanimura M</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Dodo+R%22">Dodo R</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Maruyama+Y%22">Maruyama Y</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Sawa+H%22">Sawa H</searchLink>; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo 001-0021, Japan.; International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.; One Health Research Center, Hokkaido University, Sapporo 060-0818, Japan.; Global Virus Network, 12901 Bruce B. Downs Blvd. MDC02, Tampa, Florida 33612, United States.<br /><searchLink fieldCode="AU" term="%22Watari+R%22">Watari R</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Miyano+T%22">Miyano T</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+T%22">Kato T</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+T%22">Sato T</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.<br /><searchLink fieldCode="AU" term="%22Tachibana+Y%22">Tachibana Y</searchLink>; Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21099-21119. <i>Date of Electronic Publication: </i>2025 Jul 05.
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