Toward therapeutic trials in primary lateral sclerosis.

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Title: Toward therapeutic trials in primary lateral sclerosis.
Authors: Scirocco E; Sean M. Healey & AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Allen MD; Ottawa Hospital Research Institute, Ottawa, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada., Giacomelli E; Sean M. Healey & AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ajroud-Driss S; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Andrews J; Neurological Institute of New York, Columbia University, New York, NY, USA., Banack S; Brain Chemistry Labs, Jackson, WY, USA., Bede P; Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Dublin, Ireland.; Department of Neurology, St James's Hospital, Dublin, Ireland., Benatar M; Department of Neurology and ALS Center, University of Miami, Miami, FL, USA., Cheung K; Mailman School of Public Health, Columbia University, New York, NY, USA., Corcia P; Department of Neurology, ALS Centre, CHRU Bretonneau, Tours, France., de Carvalho M; Department of Neurosciences and Mental Health, ULS Santa Maria, Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Elman L; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Fink JK; Department of Neurology, University of Michigan, Ann Arbor, MI, USA., Genge A; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada., Hardiman O; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Harms M; Neurological Institute of New York, Columbia University, New York, NY, USA., Heitzman D; Texas Neurology, Dallas, TX, USA., Jang G; Neurological Institute of New York, Columbia University, New York, NY, USA., Kano O; Department of Neurology, Toho University Faculty of Medicine, Tokyo, Japan., Kiernan MC; Neuroscience Research Australia, University of New South Wales, Sydney, Australia., Lee I; Neurological Institute of New York, Columbia University, New York, NY, USA., Ludolph A; Department of Neurology, University of Ulm, Ulm, Germany., Mehta P; Office of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA, USA., Ozdinler H; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Rezania K; Department of Neurology, University of Chicago, Chicago, IL, USA., Schito P; Experimental Neuropathology Unit, Division of Neuroscience, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sherman AV; Sean M. Healey & AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Silani V; Department of Neurology & Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milano, Italy.; Department of Pathophysiology & Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milano, Italy., Sorenson E; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Turner MR; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Van Den Berg L; Department of Neurology, University Medical Center Utrecht, Utrecht, Netherlands, and., Mitsumoto H; Neurological Institute of New York, Columbia University, New York, NY, USA., Paganoni S; Sean M. Healey & AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA.
Source: Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2025 Nov; Vol. 26 (7-8), pp. 623-630. Date of Electronic Publication: 2025 Jul 06.
Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101587185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2167-9223 (Electronic) Linking ISSN: 21678421 NLM ISO Abbreviation: Amyotroph Lateral Scler Frontotemporal Degener Subsets: MEDLINE
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Healey & AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ajroud-Driss+S%22">Ajroud-Driss S</searchLink>; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Andrews+J%22">Andrews J</searchLink>; Neurological Institute of New York, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Banack+S%22">Banack S</searchLink>; Brain Chemistry Labs, Jackson, WY, USA.<br /><searchLink fieldCode="AU" term="%22Bede+P%22">Bede P</searchLink>; Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Dublin, Ireland.; Department of Neurology, St James's Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Benatar+M%22">Benatar M</searchLink>; Department of Neurology and ALS Center, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Cheung+K%22">Cheung K</searchLink>; Mailman School of Public Health, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Corcia+P%22">Corcia P</searchLink>; Department of Neurology, ALS Centre, CHRU Bretonneau, Tours, France.<br /><searchLink fieldCode="AU" term="%22de+Carvalho+M%22">de Carvalho M</searchLink>; Department of Neurosciences and Mental Health, ULS Santa Maria, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Elman+L%22">Elman L</searchLink>; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Fink+JK%22">Fink JK</searchLink>; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Genge+A%22">Genge A</searchLink>; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Hardiman+O%22">Hardiman O</searchLink>; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Harms+M%22">Harms M</searchLink>; Neurological Institute of New York, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Heitzman+D%22">Heitzman D</searchLink>; Texas Neurology, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Jang+G%22">Jang G</searchLink>; Neurological Institute of New York, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kano+O%22">Kano O</searchLink>; Department of Neurology, Toho University Faculty of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kiernan+MC%22">Kiernan MC</searchLink>; Neuroscience Research Australia, University of New South Wales, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+I%22">Lee I</searchLink>; Neurological Institute of New York, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ludolph+A%22">Ludolph A</searchLink>; Department of Neurology, University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Mehta+P%22">Mehta P</searchLink>; Office of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ozdinler+H%22">Ozdinler H</searchLink>; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Rezania+K%22">Rezania K</searchLink>; Department of Neurology, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Schito+P%22">Schito P</searchLink>; Experimental Neuropathology Unit, Division of Neuroscience, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sherman+AV%22">Sherman AV</searchLink>; Sean M. Healey & AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Silani+V%22">Silani V</searchLink>; Department of Neurology & Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milano, Italy.; Department of Pathophysiology & Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Sorenson+E%22">Sorenson E</searchLink>; Department of Neurology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Turner+MR%22">Turner MR</searchLink>; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Van+Den+Berg+L%22">Van Den Berg L</searchLink>; Department of Neurology, University Medical Center Utrecht, Utrecht, Netherlands, and.<br /><searchLink fieldCode="AU" term="%22Mitsumoto+H%22">Mitsumoto H</searchLink>; Neurological Institute of New York, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Paganoni+S%22">Paganoni S</searchLink>; Sean M. Healey & AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA.
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