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Paediatric acute liver failure: A prospective, nationwide, population-based surveillance study in Germany.

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Title: Paediatric acute liver failure: A prospective, nationwide, population-based surveillance study in Germany.
Authors: Lenz D; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany., Abdulaziz M; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany.; Clinic for Pediatrics I, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany., Peters B; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany., Wagner M; School of Medicine, Institute of Human Genetics, Technical University of Munich, Munich, Germany.; Helmholtz Zentrum München, Institute of Neurogenomics, Computational Health Center, Neuherberg, Germany., Schlieben LD; School of Medicine, Institute of Human Genetics, Technical University of Munich, Munich, Germany.; Helmholtz Zentrum München, Institute of Neurogenomics, Computational Health Center, Neuherberg, Germany., Corman VM; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung), Berlin, Germany., Baumann U; Department of Paediatric Kidney, Division for Paediatric Gastroenterology and Hepatology, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany., Bufler P; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité Universitätsmedizin Berlin, Berlin, Germany., Dattner T; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany., Ganschow R; Department of Pediatrics, University Hospital Bonn, Bonn, Germany., Genzel K; Pediatrics, HELIOS Klinikum Erfurt, Erfurt, Germany., Hammann N; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany., Hartleif S; Paediatric Gastroenterology and Hepatology, University Children's Hospital, Eberhard Karls University Tubingen, Tubingen, Germany., Hegen B; Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Henning S; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité Universitätsmedizin Berlin, Berlin, Germany., Hoerning A; Department of Pediatrics, University Hospital Erlangen, Friedrich Alexander University of Erlangen-Nürnberg, Erlangen, Germany., Jankofsky M; Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Junge N; Department of Paediatric Kidney, Division for Paediatric Gastroenterology and Hepatology, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany., Kathemann S; Department of Pediatric Gastroenterology, Hepatology, and Transplant Medicine, Children's Hospital, University Duisburg-Essen, Essen, Germany., Knoppke B; KUNO University Children's Hospital, University Hospital Regensburg, Regensburg, Germany., Kohl-Sobania M; Department of General Pediatrics, University Medical Center Schleswig-Holstein, Kiel, Germany., Laass M; Children's Hospital, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Lainka E; Department of Pediatric Gastroenterology, Hepatology, and Transplant Medicine, Children's Hospital, University Duisburg-Essen, Essen, Germany., Lurz E; Department of Pediatrics, Division of Gastroenterology and Hepatology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany., Melter M; KUNO University Children's Hospital, University Hospital Regensburg, Regensburg, Germany., Müller H; Department of Pediatrics, Division of Neonatology and Pediatric Intensive Care, University Hospital Marburg Baldingerstraße, Marburg, Germany.; Neonatology, University Children's Hospital, Eberhard Karls University Tubingen, Tubingen, Germany., Pilic D; Department of Pediatric Gastroenterology, Hepatology, and Transplant Medicine, Children's Hospital, University Duisburg-Essen, Essen, Germany., Ries M; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany., Schiefele L; Department of Pediatrics and Adolescent Medicine, Division of Neonatology and Pediatrics, University Medical Center Ulm, Ulm University, Ulm, Germany., Schwerd T; Department of Pediatrics, Division of Gastroenterology and Hepatology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany., Sturm E; Paediatric Gastroenterology and Hepatology, University Children's Hospital, Eberhard Karls University Tubingen, Tubingen, Germany., Wegner M; Department of Pediatrics, University Hospital Greifswald, Greifswald, Germany., Urschitz MS; German Paediatric Surveillance Unit (ESPED), Division of Paediatric Epidemiology, Institute of Medical Biostatistics, Epidemiology, and Informatics (IMBEI), University Medical Centre of the Johannes Gutenberg University, Mainz, Germany., Garbade SF; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany., Wenning D; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany., Drosten C; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung), Berlin, Germany., Fichtner A; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany., Kölker S; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany., Hoffmann GF; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany., Prokisch H; School of Medicine, Institute of Human Genetics, Technical University of Munich, Munich, Germany.; Helmholtz Zentrum München, Institute of Neurogenomics, Computational Health Center, Neuherberg, Germany., Staufner C; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany.
Source: Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2025 Sep; Vol. 81 (3), pp. 653-662. Date of Electronic Publication: 2025 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 8211545 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-4801 (Electronic) Linking ISSN: 02772116 NLM ISO Abbreviation: J Pediatr Gastroenterol Nutr Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Paediatric acute liver failure: A prospective, nationwide, population-based surveillance study in Germany.
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  Data: <searchLink fieldCode="AU" term="%22Lenz+D%22">Lenz D</searchLink>; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Abdulaziz+M%22">Abdulaziz M</searchLink>; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany.; Clinic for Pediatrics I, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Peters+B%22">Peters B</searchLink>; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+M%22">Wagner M</searchLink>; School of Medicine, Institute of Human Genetics, Technical University of Munich, Munich, Germany.; Helmholtz Zentrum München, Institute of Neurogenomics, Computational Health Center, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schlieben+LD%22">Schlieben LD</searchLink>; School of Medicine, Institute of Human Genetics, Technical University of Munich, Munich, Germany.; Helmholtz Zentrum München, Institute of Neurogenomics, Computational Health Center, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Corman+VM%22">Corman VM</searchLink>; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Baumann+U%22">Baumann U</searchLink>; Department of Paediatric Kidney, Division for Paediatric Gastroenterology and Hepatology, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Bufler+P%22">Bufler P</searchLink>; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Dattner+T%22">Dattner T</searchLink>; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ganschow+R%22">Ganschow R</searchLink>; Department of Pediatrics, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Genzel+K%22">Genzel K</searchLink>; Pediatrics, HELIOS Klinikum Erfurt, Erfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Hammann+N%22">Hammann N</searchLink>; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hartleif+S%22">Hartleif S</searchLink>; Paediatric Gastroenterology and Hepatology, University Children's Hospital, Eberhard Karls University Tubingen, Tubingen, Germany.<br /><searchLink fieldCode="AU" term="%22Hegen+B%22">Hegen B</searchLink>; Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Henning+S%22">Henning S</searchLink>; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hoerning+A%22">Hoerning A</searchLink>; Department of Pediatrics, University Hospital Erlangen, Friedrich Alexander University of Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Jankofsky+M%22">Jankofsky M</searchLink>; Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Junge+N%22">Junge N</searchLink>; Department of Paediatric Kidney, Division for Paediatric Gastroenterology and Hepatology, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Kathemann+S%22">Kathemann S</searchLink>; Department of Pediatric Gastroenterology, Hepatology, and Transplant Medicine, Children's Hospital, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Knoppke+B%22">Knoppke B</searchLink>; KUNO University Children's Hospital, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kohl-Sobania+M%22">Kohl-Sobania M</searchLink>; Department of General Pediatrics, University Medical Center Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Laass+M%22">Laass M</searchLink>; Children's Hospital, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Lainka+E%22">Lainka E</searchLink>; Department of Pediatric Gastroenterology, Hepatology, and Transplant Medicine, Children's Hospital, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Lurz+E%22">Lurz E</searchLink>; Department of Pediatrics, Division of Gastroenterology and Hepatology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Melter+M%22">Melter M</searchLink>; KUNO University Children's Hospital, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+H%22">Müller H</searchLink>; Department of Pediatrics, Division of Neonatology and Pediatric Intensive Care, University Hospital Marburg Baldingerstraße, Marburg, Germany.; Neonatology, University Children's Hospital, Eberhard Karls University Tubingen, Tubingen, Germany.<br /><searchLink fieldCode="AU" term="%22Pilic+D%22">Pilic D</searchLink>; Department of Pediatric Gastroenterology, Hepatology, and Transplant Medicine, Children's Hospital, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Ries+M%22">Ries M</searchLink>; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schiefele+L%22">Schiefele L</searchLink>; Department of Pediatrics and Adolescent Medicine, Division of Neonatology and Pediatrics, University Medical Center Ulm, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Schwerd+T%22">Schwerd T</searchLink>; Department of Pediatrics, Division of Gastroenterology and Hepatology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Sturm+E%22">Sturm E</searchLink>; Paediatric Gastroenterology and Hepatology, University Children's Hospital, Eberhard Karls University Tubingen, Tubingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wegner+M%22">Wegner M</searchLink>; Department of Pediatrics, University Hospital Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Urschitz+MS%22">Urschitz MS</searchLink>; German Paediatric Surveillance Unit (ESPED), Division of Paediatric Epidemiology, Institute of Medical Biostatistics, Epidemiology, and Informatics (IMBEI), University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Garbade+SF%22">Garbade SF</searchLink>; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wenning+D%22">Wenning D</searchLink>; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Drosten+C%22">Drosten C</searchLink>; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.; German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Fichtner+A%22">Fichtner A</searchLink>; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kölker+S%22">Kölker S</searchLink>; Department I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+GF%22">Hoffmann GF</searchLink>; 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