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Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer.

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Title: Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer.
Authors: Simoes AR; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain., Carlés González S; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain., Lopez-Doldan MDC; Oncological Pharmacy Unit, Complexo Hospitalario Universitario de Ourense, Ourense, Spain., Duran G; University Hospital of Santiago de Compostela Pharmacy Service, Santiago de Compostela, Spain., Fernández-Montes A; Medical Oncology Unit, Complexo Hospitalario Universitario de Ourense, Ourense, Spain., Fernandez MP; Oncological Pharmacy Unit, Complexo Hospitalario Universitario de Ourense, Ourense, Spain., Salgado Fernandez M; Medical Oncology Unit, Complexo Hospitalario Universitario de Ourense, Ourense, Spain., Garcia Mata J; Medical Oncology Unit, Complexo Hospitalario Universitario de Ourense, Ourense, Spain., Paez D; Hospital de la Santa Creu i Sant Pau, Medical Oncology Department, Barcelona, Spain.; Institut d'Investigacio Biomedica Sant Pau, Translational Medical Oncology Laboratory, Barcelona, Spain.; Center for Biomedical Research in Network on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain., Riera P; Institut d'Investigacio Biomedica Sant Pau, Translational Medical Oncology Laboratory, Barcelona, Spain.; Pharmacy Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Center for Biomedical Research in Network on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain., Guino E; Catalan Institute of Oncology, Oncology Data Analytics Program, Barcelona, Spain.; Bellvitge Institute for Biomedical Research, Colorectal Cancer Group; Molecular Mechanisms and Experimental Therapy in Oncology (ONCOBELL) Program, Barcelona, Spain.; Biomedical Research Center in Network of Epidemiology and Public Health, Consortium (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain., Lopez-Fernandez L; Hospital General Universitario Gregorio Marañón Servicio de Farmacia, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain., Garcia de Santiago B; Infanta Sofia University Hospital, Pharmacy Service, Madrid, Spain., López Aspiroz E; Infanta Sofia University Hospital, Pharmacy Service, Madrid, Spain.; Universidad Europea de Madrid, Faculty of Medicine, Health and Sports, Madrid, Spain., Rojas A; Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico., Castells A; Hospital Clínic Barcelona, Gastroenterology Unit, Barcelona, Spain.; Gastroenterology Department, Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain., Castellvi-Bel S; Hospital Clínic Barcelona, Gastroenterology Unit, Barcelona, Spain.; Gastroenterology Department, Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Hospital Clínic Barcelona, Gastroenterology Department, Barcelona, Spain., Ruiz Ponte C; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.; Galician Public Foundation for Genomic Medicine (FPGMX), Santiago de Compostela, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain., Vymetalkova V; Department of Molecular Biology of Cancer, Charles University, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic., Carracedo A; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.; Galician Public Foundation for Genomic Medicine (FPGMX), Santiago de Compostela, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.; Genomic Medicine Group, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Fernandez-Rozadilla C; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.; Galician Public Foundation for Genomic Medicine (FPGMX), Santiago de Compostela, Spain.; Genomic Medicine Group, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Source: British journal of pharmacology [Br J Pharmacol] 2025 Nov; Vol. 182 (21), pp. 5340-5354. Date of Electronic Publication: 2025 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Simoes+AR%22">Simoes AR</searchLink>; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Carlés+González+S%22">Carlés González S</searchLink>; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Lopez-Doldan+MDC%22">Lopez-Doldan MDC</searchLink>; Oncological Pharmacy Unit, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.<br /><searchLink fieldCode="AU" term="%22Duran+G%22">Duran G</searchLink>; University Hospital of Santiago de Compostela Pharmacy Service, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Montes+A%22">Fernández-Montes A</searchLink>; Medical Oncology Unit, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandez+MP%22">Fernandez MP</searchLink>; Oncological Pharmacy Unit, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.<br /><searchLink fieldCode="AU" term="%22Salgado+Fernandez+M%22">Salgado Fernandez M</searchLink>; Medical Oncology Unit, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia+Mata+J%22">Garcia Mata J</searchLink>; Medical Oncology Unit, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.<br /><searchLink fieldCode="AU" term="%22Paez+D%22">Paez D</searchLink>; Hospital de la Santa Creu i Sant Pau, Medical Oncology Department, Barcelona, Spain.; Institut d'Investigacio Biomedica Sant Pau, Translational Medical Oncology Laboratory, Barcelona, Spain.; Center for Biomedical Research in Network on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Riera+P%22">Riera P</searchLink>; Institut d'Investigacio Biomedica Sant Pau, Translational Medical Oncology Laboratory, Barcelona, Spain.; Pharmacy Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Center for Biomedical Research in Network on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Guino+E%22">Guino E</searchLink>; Catalan Institute of Oncology, Oncology Data Analytics Program, Barcelona, Spain.; Bellvitge Institute for Biomedical Research, Colorectal Cancer Group; Molecular Mechanisms and Experimental Therapy in Oncology (ONCOBELL) Program, Barcelona, Spain.; Biomedical Research Center in Network of Epidemiology and Public Health, Consortium (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lopez-Fernandez+L%22">Lopez-Fernandez L</searchLink>; Hospital General Universitario Gregorio Marañón Servicio de Farmacia, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia+de+Santiago+B%22">Garcia de Santiago B</searchLink>; Infanta Sofia University Hospital, Pharmacy Service, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22López+Aspiroz+E%22">López Aspiroz E</searchLink>; Infanta Sofia University Hospital, Pharmacy Service, Madrid, Spain.; Universidad Europea de Madrid, Faculty of Medicine, Health and Sports, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rojas+A%22">Rojas A</searchLink>; Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico.<br /><searchLink fieldCode="AU" term="%22Castells+A%22">Castells A</searchLink>; Hospital Clínic Barcelona, Gastroenterology Unit, Barcelona, Spain.; Gastroenterology Department, Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Castellvi-Bel+S%22">Castellvi-Bel S</searchLink>; Hospital Clínic Barcelona, Gastroenterology Unit, Barcelona, Spain.; Gastroenterology Department, Institut d' Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Hospital Clínic Barcelona, Gastroenterology Department, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ruiz+Ponte+C%22">Ruiz Ponte C</searchLink>; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.; Galician Public Foundation for Genomic Medicine (FPGMX), Santiago de Compostela, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vymetalkova+V%22">Vymetalkova V</searchLink>; Department of Molecular Biology of Cancer, Charles University, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Carracedo+A%22">Carracedo A</searchLink>; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.; Galician Public Foundation for Genomic Medicine (FPGMX), Santiago de Compostela, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.; Genomic Medicine Group, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandez-Rozadilla+C%22">Fernandez-Rozadilla C</searchLink>; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.; Galician Public Foundation for Genomic Medicine (FPGMX), Santiago de Compostela, Spain.; Genomic Medicine Group, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
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  Data: <searchLink fieldCode="JN" term="%227502536%22">British journal of pharmacology</searchLink> [Br J Pharmacol] 2025 Nov; Vol. 182 (21), pp. 5340-5354. <i>Date of Electronic Publication: </i>2025 Jul 07.
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