BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza.

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Title: BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza.
Authors: Soni S; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210., Yildiz S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029., Allen EK; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105., Petersen H; Chronic Obstructive Pulmonary Disease Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108., Peeples M; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205., El Zahed S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029., Rosas L; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210., Anang V; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210., Antonescu L; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210., Nho RS; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210., Mora AL; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210., Horowitz JC; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210., Rojas M; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210., Medina RA; Pathology Advanced Translational Research Unit, Department of Pathology and Laboratory Medicine Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322., Thomas PG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; The Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029., Tesfaigzi Y; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Mebratu YA; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jul 15; Vol. 122 (28), pp. e2424367122. Date of Electronic Publication: 2025 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Soni+S%22">Soni S</searchLink>; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Yildiz+S%22">Yildiz S</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.<br /><searchLink fieldCode="AU" term="%22Allen+EK%22">Allen EK</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105.<br /><searchLink fieldCode="AU" term="%22Petersen+H%22">Petersen H</searchLink>; Chronic Obstructive Pulmonary Disease Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108.<br /><searchLink fieldCode="AU" term="%22Peeples+M%22">Peeples M</searchLink>; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205.<br /><searchLink fieldCode="AU" term="%22El+Zahed+S%22">El Zahed S</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.<br /><searchLink fieldCode="AU" term="%22Rosas+L%22">Rosas L</searchLink>; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Anang+V%22">Anang V</searchLink>; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Antonescu+L%22">Antonescu L</searchLink>; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Nho+RS%22">Nho RS</searchLink>; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Mora+AL%22">Mora AL</searchLink>; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Horowitz+JC%22">Horowitz JC</searchLink>; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Rojas+M%22">Rojas M</searchLink>; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.<br /><searchLink fieldCode="AU" term="%22Medina+RA%22">Medina RA</searchLink>; Pathology Advanced Translational Research Unit, Department of Pathology and Laboratory Medicine Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322.<br /><searchLink fieldCode="AU" term="%22Thomas+PG%22">Thomas PG</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105.<br /><searchLink fieldCode="AU" term="%22García-Sastre+A%22">García-Sastre A</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.; The Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY 10029.<br /><searchLink fieldCode="AU" term="%22Tesfaigzi+Y%22">Tesfaigzi Y</searchLink>; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Mebratu+YA%22">Mebratu YA</searchLink>; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.
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