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HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise.

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Title: HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise.
Authors: Ehrlich AM; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., MacGregor KA; Integrative Physiology Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-171 77, Sweden., Ashcroft SP; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Small L; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Altıntaş A; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Chibalin AV; Integrative Physiology Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-171 77, Sweden., Anagho-Mattanovich M; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Stocks B; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.; Integrative Physiology Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-171 77, Sweden., Moritz T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Treebak JT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Zierath JR; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.; Integrative Physiology Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-171 77, Sweden.; Integrative Physiology Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm SE-171 77, Sweden.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jul 15; Vol. 122 (28), pp. e2504080122. Date of Electronic Publication: 2025 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ehrlich+AM%22">Ehrlich AM</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.<br /><searchLink fieldCode="AU" term="%22MacGregor+KA%22">MacGregor KA</searchLink>; Integrative Physiology Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-171 77, Sweden.<br /><searchLink fieldCode="AU" term="%22Ashcroft+SP%22">Ashcroft SP</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.<br /><searchLink fieldCode="AU" term="%22Small+L%22">Small L</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.<br /><searchLink fieldCode="AU" term="%22Altıntaş+A%22">Altıntaş A</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.<br /><searchLink fieldCode="AU" term="%22Chibalin+AV%22">Chibalin AV</searchLink>; Integrative Physiology Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-171 77, Sweden.<br /><searchLink fieldCode="AU" term="%22Anagho-Mattanovich+M%22">Anagho-Mattanovich M</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.<br /><searchLink fieldCode="AU" term="%22Stocks+B%22">Stocks B</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.; Integrative Physiology Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-171 77, Sweden.<br /><searchLink fieldCode="AU" term="%22Moritz+T%22">Moritz T</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.<br /><searchLink fieldCode="AU" term="%22Treebak+JT%22">Treebak JT</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.<br /><searchLink fieldCode="AU" term="%22Zierath+JR%22">Zierath JR</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.; Integrative Physiology Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-171 77, Sweden.; Integrative Physiology Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm SE-171 77, Sweden.
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