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CDK4/6 inhibition in advanced chordoma: final results of the NCT PMO-1601 trial.

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Title: CDK4/6 inhibition in advanced chordoma: final results of the NCT PMO-1601 trial.
Authors: Teleanu MV; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany. Electronic address: maria-veronica.teleanu@nct-heidelberg.de., Heilig CE; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany., Pirmann S; Computational Oncology Group, Molecular Precision Oncology Program, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany., Hamacher R; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany., Bauer S; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany., Gaidzik VI; Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany., Mayer-Steinacker R; Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany., Al-Sabah J; Computational Oncology Group, Molecular Precision Oncology Program, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany., Roldan Pinzon SSL; NCT Trial Center, DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Süße H; NCT Trial Center, DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Freitag A; NCT Trial Center, DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Horak P; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany., Kreutzfeldt S; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany., Hutter B; Computational Oncology Group, Molecular Precision Oncology Program, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany., Hüllein J; Computational Oncology Group, Molecular Precision Oncology Program, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany., Sedlaczek O; Divison of Radiology, German Cancer Research Center, Heidelberg, Germany., Lehner B; Department of Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany., Egerer G; Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany., Jäger D; Department of Medical Oncology, NCT Heidelberg and Heidelberg University Hospital, Heidelberg, Germany., Müller-Tidow C; Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany., Hübschmann D; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany; Computational Oncology Group, Molecular Precision Oncology Program, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Pattern Recognition and Digital Medicine Group, Heidelberg, Germany; Innovation and Service Unit for Bioinformatics and Precision Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany., von Kalle C; Berlin Institute of Health, Berlin, Germany., Barth TFE; Institute of Pathology, Ulm University Hospital, Ulm, Germany., Fröhling S; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany., Schlenk RF; Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany; NCT Trial Center, DKFZ and Heidelberg University Hospital, Heidelberg, Germany; Department of Medical Oncology, NCT Heidelberg and Heidelberg University Hospital, Heidelberg, Germany.
Source: ESMO open [ESMO Open] 2025 Jul; Vol. 10 (7), pp. 105498. Date of Electronic Publication: 2025 Jul 07.
Publication Type: Journal Article; Clinical Trial, Phase II
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CDK4/6 inhibition in advanced chordoma: final results of the NCT PMO-1601 trial.
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  Data: <searchLink fieldCode="AU" term="%22Teleanu+MV%22">Teleanu MV</searchLink>; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany. Electronic address: maria-veronica.teleanu@nct-heidelberg.de.<br /><searchLink fieldCode="AU" term="%22Heilig+CE%22">Heilig CE</searchLink>; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pirmann+S%22">Pirmann S</searchLink>; Computational Oncology Group, Molecular Precision Oncology Program, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hamacher+R%22">Hamacher R</searchLink>; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Bauer+S%22">Bauer S</searchLink>; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Gaidzik+VI%22">Gaidzik VI</searchLink>; Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Mayer-Steinacker+R%22">Mayer-Steinacker R</searchLink>; Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Al-Sabah+J%22">Al-Sabah J</searchLink>; Computational Oncology Group, Molecular Precision Oncology Program, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Roldan+Pinzon+SSL%22">Roldan Pinzon SSL</searchLink>; NCT Trial Center, DKFZ and Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Süße+H%22">Süße H</searchLink>; NCT Trial Center, DKFZ and Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Freitag+A%22">Freitag A</searchLink>; NCT Trial Center, DKFZ and Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Horak+P%22">Horak P</searchLink>; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kreutzfeldt+S%22">Kreutzfeldt S</searchLink>; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hutter+B%22">Hutter B</searchLink>; Computational Oncology Group, Molecular Precision Oncology Program, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hüllein+J%22">Hüllein J</searchLink>; Computational Oncology Group, Molecular Precision Oncology Program, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sedlaczek+O%22">Sedlaczek O</searchLink>; Divison of Radiology, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Lehner+B%22">Lehner B</searchLink>; Department of Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Egerer+G%22">Egerer G</searchLink>; Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jäger+D%22">Jäger D</searchLink>; Department of Medical Oncology, NCT Heidelberg and Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Müller-Tidow+C%22">Müller-Tidow C</searchLink>; Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hübschmann+D%22">Hübschmann D</searchLink>; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany; Computational Oncology Group, Molecular Precision Oncology Program, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Pattern Recognition and Digital Medicine Group, Heidelberg, Germany; Innovation and Service Unit for Bioinformatics and Precision Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22von+Kalle+C%22">von Kalle C</searchLink>; Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Barth+TFE%22">Barth TFE</searchLink>; Institute of Pathology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Fröhling+S%22">Fröhling S</searchLink>; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schlenk+RF%22">Schlenk RF</searchLink>; Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany; NCT Trial Center, DKFZ and Heidelberg University Hospital, Heidelberg, Germany; Department of Medical Oncology, NCT Heidelberg and Heidelberg University Hospital, Heidelberg, Germany.
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