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The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models.

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Title: The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models.
Authors: Kyula-Currie J; The Institute of Cancer Research, London, UK. joan.kyula@icr.ac.uk., Roulstone V; The Institute of Cancer Research, London, UK., Wright J; The Institute of Cancer Research, London, UK., Butera F; The Institute of Cancer Research, London, UK., Legrand A; The Institute of Cancer Research, London, UK., Elliott R; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research, London, UK., McLaughlin M; The Institute of Cancer Research, London, UK., Bozhanova G; The Institute of Cancer Research, London, UK., Krastev D; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research, London, UK., Pettitt S; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research, London, UK., Tenev T; The Institute of Cancer Research, London, UK., Dillon M; The Institute of Cancer Research, London, UK., Foo S; The Institute of Cancer Research, London, UK., Patin EC; The Institute of Cancer Research, London, UK., Jennings V; The Institute of Cancer Research, London, UK., Chan Wah Hak C; The Institute of Cancer Research, London, UK., Appleton E; The Institute of Cancer Research, London, UK., Wongariyapak A; The Institute of Cancer Research, London, UK., Pedersen M; The Institute of Cancer Research, London, UK., Rullan A; The Institute of Cancer Research, London, UK., Choudhary J; The Institute of Cancer Research, London, UK., Bakal C; The Institute of Cancer Research, London, UK., Meier P; The Institute of Cancer Research, London, UK., Lord CJ; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research, London, UK., Melcher A; The Institute of Cancer Research, London, UK., Harrington KJ; The Institute of Cancer Research, London, UK.
Source: Nature communications [Nat Commun] 2025 Jul 08; Vol. 16 (1), pp. 6299. Date of Electronic Publication: 2025 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models.
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  Data: <searchLink fieldCode="AU" term="%22Kyula-Currie+J%22">Kyula-Currie J</searchLink>; The Institute of Cancer Research, London, UK. joan.kyula@icr.ac.uk.<br /><searchLink fieldCode="AU" term="%22Roulstone+V%22">Roulstone V</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Wright+J%22">Wright J</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Butera+F%22">Butera F</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Legrand+A%22">Legrand A</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Elliott+R%22">Elliott R</searchLink>; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research, London, UK.<br /><searchLink fieldCode="AU" term="%22McLaughlin+M%22">McLaughlin M</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Bozhanova+G%22">Bozhanova G</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Krastev+D%22">Krastev D</searchLink>; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Pettitt+S%22">Pettitt S</searchLink>; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Tenev+T%22">Tenev T</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Dillon+M%22">Dillon M</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Foo+S%22">Foo S</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Patin+EC%22">Patin EC</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Jennings+V%22">Jennings V</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Chan+Wah+Hak+C%22">Chan Wah Hak C</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Appleton+E%22">Appleton E</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Wongariyapak+A%22">Wongariyapak A</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Pedersen+M%22">Pedersen M</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Rullan+A%22">Rullan A</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Choudhary+J%22">Choudhary J</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Bakal+C%22">Bakal C</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Meier+P%22">Meier P</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Lord+CJ%22">Lord CJ</searchLink>; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Melcher+A%22">Melcher A</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Harrington+KJ%22">Harrington KJ</searchLink>; The Institute of Cancer Research, London, UK.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Jul 08; Vol. 16 (1), pp. 6299. <i>Date of Electronic Publication: </i>2025 Jul 08.
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