Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples.

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Title: Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples.
Authors: Ju CW; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA.; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA., Lyu R; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA., Li H; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA., Wei J; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA., Parra Vitela AJ; Colon and Rectal Surgery, Advocate Lutheran General Hospital, Park Ridge, IL, USA., Dougherty U; Department of Medicine, The University of Chicago, Chicago, IL, USA., Kwesi A; Department of Medicine, The University of Chicago, Chicago, IL, USA., Luna A; Department of Medicine, The University of Chicago, Chicago, IL, USA., Zhu X; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA., Shen S; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.; Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, China., Liu Y; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Wang L; The Laboratory of Microbiome and Microecological Technology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China., Cui X; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA., Xu Y; Department of Chemistry, New York University, New York, NY, USA., Jiang B; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA., Ji Y; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA., Xia P; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA., West-Szymanski DC; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA., Sun C; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA., Zhong Y; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA., Ye C; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA., Moran A; Department of Pathology, The University of Chicago, Chicago, IL, USA., Lehmann C; Department of Medicine, The University of Chicago, Chicago, IL, USA., Pamer E; Department of Medicine, The University of Chicago, Chicago, IL, USA., Zhang W; Department of Preventive Medicine and The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Bissonnette M; Department of Medicine, The University of Chicago, Chicago, IL, USA. mbissonn@bsd.uchicago.edu., Zhang LS; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China. zhangls@ust.hk.; Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, China. zhangls@ust.hk., He C; Department of Chemistry, The University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.
Source: Nature biotechnology [Nat Biotechnol] 2026 May; Vol. 44 (5), pp. 752-758. Date of Electronic Publication: 2025 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Bissonnette+M%22">Bissonnette M</searchLink>; Department of Medicine, The University of Chicago, Chicago, IL, USA. mbissonn@bsd.uchicago.edu.<br /><searchLink fieldCode="AU" term="%22Zhang+LS%22">Zhang LS</searchLink>; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China. zhangls@ust.hk.; Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, China. zhangls@ust.hk.<br /><searchLink fieldCode="AU" term="%22He+C%22">He C</searchLink>; Department of Chemistry, The University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.
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