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VINCENT: A randomized-controlled trial evaluating venetoclax plus azacitidine versus intensive chemotherapy in patients with newly diagnosed, NPM1-mutated AML.

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Title: VINCENT: A randomized-controlled trial evaluating venetoclax plus azacitidine versus intensive chemotherapy in patients with newly diagnosed, NPM1-mutated AML.
Authors: Kretschmer L; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany. lydia.kretschmer@ukdd.de., Ruhnke L; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany., Schliemann C; Department of Medicine A, University Hospital Münster, Münster, Germany., Fransecky L; Department of Hematology and Oncology, University Hospital Schleswig- Holstein, Campus Kiel, Kiel, Germany., Steffen B; Department of Internal Medicine II, University Hospital Frankfurt, Frankfurt, Germany., Kaufmann M; Robert Bosch Hospital, Stuttgart, Germany., Burchert A; Department of Internal Medicine, Hematology, Oncology and Immunology, University Hospital Marburg, Marburg, Germany., Schmid C; Department of Internal Medicine II, Hematology and Oncology, University Hospital Augsburg, Augsburg, Germany., Hanoun M; Department of Hematology and Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Sauer T; Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany., Metzeler KH; Department of Internal Medicine I, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany., Schäfer-Eckart K; Department of Internal Medicine V, Klinikum Nürnberg, Paracelsus Medical University, Nuremberg, Germany., Hänel M; Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany., Crysandt M; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, Center for Integrated Oncology Aachen, Bonn Cologne Duesseldorf, Aachen, Germany., Jäger P; University Hospital of Düsseldorf, Düsseldorf, Germany., Krause SW; Department of Internal Medicine V, University Hospital Erlangen, Erlangen, Germany., Dierks C; University Hospital Halle, Halle, Germany., Klein S; University Medical Centre Mannheim, Mannheim, Germany., Maguire N; Barmherzige Brüder Hospital, Regensburg, Germany., Frenzel LP; Department I of Internal Medicine, Faculty of Medicine and Cologne University Hospital, Center for Integrated Oncology Aachen, University of Cologne, Bonn, Cologne, Düsseldorf, Cologne, Germany., Bücklein VL; LMU Hospital, Munich, Germany., Blau W; Department of Internal Medicine III, Hematology, Oncology and Palliative Care, Helios Dr. Horst Schmidt Hospital Wiesbaden, Wiesbaden, Germany., Kaiser U; Department of Hematology, Oncology and Immunology, St. Bernward Hospital, Hildesheim, Germany., Wegehenkel K; University Hospital OWL/Bielefeld Hospital, Bielefeld, Germany., Höllein A; Department of Internal Medicine III, Hematology and Oncology, Rotkreuzklinikum München, Munich, Germany., Seggewiss-Bernhardt R; Department of Internal Medicine V, Sozialstiftung Bamberg, Bamberg, Germany.; Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Markgraf W; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany., Fiebig F; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany., Harig A; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany., Schmidt-Brücken K; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany., Thiede C; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany.; AgenDix GmbH, Dresden, Germany., Middeke JM; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany., Dillon R; King's College, London, UK., Baldus CD; Department of Hematology and Oncology, University Hospital Schleswig- Holstein, Campus Kiel, Kiel, Germany., Serve H; Department of Internal Medicine II, University Hospital Frankfurt, Frankfurt, Germany., Spiekermann K; LMU Hospital, Munich, Germany., Hiddemann W; LMU Hospital, Munich, Germany., Schlenk RF; Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany., Müller-Tidow C; Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany., Bornhäuser M; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany., Röllig C; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany.
Source: Annals of hematology [Ann Hematol] 2025 Jul; Vol. 104 (7), pp. 3647-3654. Date of Electronic Publication: 2025 Jul 09.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: VINCENT: A randomized-controlled trial evaluating venetoclax plus azacitidine versus intensive chemotherapy in patients with newly diagnosed, NPM1-mutated AML.
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  Data: <searchLink fieldCode="AU" term="%22Kretschmer+L%22">Kretschmer L</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany. lydia.kretschmer@ukdd.de.<br /><searchLink fieldCode="AU" term="%22Ruhnke+L%22">Ruhnke L</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Schliemann+C%22">Schliemann C</searchLink>; Department of Medicine A, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Fransecky+L%22">Fransecky L</searchLink>; Department of Hematology and Oncology, University Hospital Schleswig- Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Steffen+B%22">Steffen B</searchLink>; Department of Internal Medicine II, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Kaufmann+M%22">Kaufmann M</searchLink>; Robert Bosch Hospital, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Burchert+A%22">Burchert A</searchLink>; Department of Internal Medicine, Hematology, Oncology and Immunology, University Hospital Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmid+C%22">Schmid C</searchLink>; Department of Internal Medicine II, Hematology and Oncology, University Hospital Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hanoun+M%22">Hanoun M</searchLink>; Department of Hematology and Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Sauer+T%22">Sauer T</searchLink>; Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Metzeler+KH%22">Metzeler KH</searchLink>; Department of Internal Medicine I, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Schäfer-Eckart+K%22">Schäfer-Eckart K</searchLink>; Department of Internal Medicine V, Klinikum Nürnberg, Paracelsus Medical University, Nuremberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hänel+M%22">Hänel M</searchLink>; Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany.<br /><searchLink fieldCode="AU" term="%22Crysandt+M%22">Crysandt M</searchLink>; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, Center for Integrated Oncology Aachen, Bonn Cologne Duesseldorf, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Jäger+P%22">Jäger P</searchLink>; University Hospital of Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Krause+SW%22">Krause SW</searchLink>; Department of Internal Medicine V, University Hospital Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Dierks+C%22">Dierks C</searchLink>; University Hospital Halle, Halle, Germany.<br /><searchLink fieldCode="AU" term="%22Klein+S%22">Klein S</searchLink>; 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University Hospital OWL/Bielefeld Hospital, Bielefeld, Germany.<br /><searchLink fieldCode="AU" term="%22Höllein+A%22">Höllein A</searchLink>; Department of Internal Medicine III, Hematology and Oncology, Rotkreuzklinikum München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Seggewiss-Bernhardt+R%22">Seggewiss-Bernhardt R</searchLink>; Department of Internal Medicine V, Sozialstiftung Bamberg, Bamberg, Germany.; Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Markgraf+W%22">Markgraf W</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Fiebig+F%22">Fiebig F</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Harig+A%22">Harig A</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt-Brücken+K%22">Schmidt-Brücken K</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Thiede+C%22">Thiede C</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany.; AgenDix GmbH, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Middeke+JM%22">Middeke JM</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Dillon+R%22">Dillon R</searchLink>; King's College, London, UK.<br /><searchLink fieldCode="AU" term="%22Baldus+CD%22">Baldus CD</searchLink>; Department of Hematology and Oncology, University Hospital Schleswig- Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Serve+H%22">Serve H</searchLink>; Department of Internal Medicine II, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Spiekermann+K%22">Spiekermann K</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%229107334%22">Annals of hematology</searchLink> [Ann Hematol] 2025 Jul; Vol. 104 (7), pp. 3647-3654. <i>Date of Electronic Publication: </i>2025 Jul 09.
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