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Translational Pharmacokinetics of Icotrokinra, a Targeted Oral Peptide that Selectively Blocks Interleukin-23 Receptor and Inhibits Signaling.

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Title: Translational Pharmacokinetics of Icotrokinra, a Targeted Oral Peptide that Selectively Blocks Interleukin-23 Receptor and Inhibits Signaling.
Authors: Knight B; Johnson & Johnson, San Diego, CA, USA. bknight3@its.jnj.com., Tammara B; Johnson & Johnson, Spring House, PA, USA., Modi NB; Protagonist Therapeutics, Inc, Newark, CA, USA., Dallas S; Johnson & Johnson, Spring House, PA, USA., Mardirosian S; Johnson & Johnson, Spring House, PA, USA., Wang J; Johnson & Johnson, Spring House, PA, USA., Laenen A; Johnson & Johnson, Beerse, Belgium., Leclercq L; Johnson & Johnson, Beerse, Belgium., DiLoreto K; Johnson & Johnson, Spring House, PA, USA., Adriaenssen L; Johnson & Johnson, Beerse, Belgium., Moss D; Johnson & Johnson, Beerse, Belgium., Polidori D; Johnson & Johnson, San Diego, CA, USA., Chaudhuri SR; Johnson & Johnson, San Diego, CA, USA., Park S; Johnson & Johnson, Spring House, PA, USA., Sensenhauser C; Johnson & Johnson, Spring House, PA, USA., Ndifor A; Johnson & Johnson, San Diego, CA, USA., Sukumaran S; Johnson & Johnson, Spring House, PA, USA., Baguet T; Johnson & Johnson, Beerse, Belgium., Shi Y; Johnson & Johnson, Spring House, PA, USA., Patel S; Johnson & Johnson, Spring House, PA, USA., Geist B; Johnson & Johnson, Spring House, PA, USA., Fourie A; Johnson & Johnson, San Diego, CA, USA., Patch R; Johnson & Johnson, Spring House, PA, USA., Sun C; Johnson & Johnson, Spring House, PA, USA.; Pinnacle Medicines, Doylestown, PA, USA., Barros SA; Johnson & Johnson, Spring House, PA, USA., Somani S; Johnson & Johnson, Spring House, PA, USA.; Pinnacle Medicines, Doylestown, PA, USA., Monshouwer M; Johnson & Johnson, Beerse, Belgium.
Source: Dermatology and therapy [Dermatol Ther (Heidelb)] 2025 Sep; Vol. 15 (9), pp. 2495-2520. Date of Electronic Publication: 2025 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Springer Healthcare Communications Country of Publication: Switzerland NLM ID: 101590450 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2193-8210 (Print) NLM ISO Abbreviation: Dermatol Ther (Heidelb) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Translational Pharmacokinetics of Icotrokinra, a Targeted Oral Peptide that Selectively Blocks Interleukin-23 Receptor and Inhibits Signaling.
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  Data: <searchLink fieldCode="AU" term="%22Knight+B%22">Knight B</searchLink>; Johnson & Johnson, San Diego, CA, USA. bknight3@its.jnj.com.<br /><searchLink fieldCode="AU" term="%22Tammara+B%22">Tammara B</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Modi+NB%22">Modi NB</searchLink>; Protagonist Therapeutics, Inc, Newark, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dallas+S%22">Dallas S</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mardirosian+S%22">Mardirosian S</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Laenen+A%22">Laenen A</searchLink>; Johnson & Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Leclercq+L%22">Leclercq L</searchLink>; Johnson & Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22DiLoreto+K%22">DiLoreto K</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Adriaenssen+L%22">Adriaenssen L</searchLink>; Johnson & Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Moss+D%22">Moss D</searchLink>; Johnson & Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Polidori+D%22">Polidori D</searchLink>; Johnson & Johnson, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chaudhuri+SR%22">Chaudhuri SR</searchLink>; Johnson & Johnson, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sensenhauser+C%22">Sensenhauser C</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ndifor+A%22">Ndifor A</searchLink>; Johnson & Johnson, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sukumaran+S%22">Sukumaran S</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Baguet+T%22">Baguet T</searchLink>; Johnson & Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+S%22">Patel S</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Geist+B%22">Geist B</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Fourie+A%22">Fourie A</searchLink>; Johnson & Johnson, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Patch+R%22">Patch R</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sun+C%22">Sun C</searchLink>; Johnson & Johnson, Spring House, PA, USA.; Pinnacle Medicines, Doylestown, PA, USA.<br /><searchLink fieldCode="AU" term="%22Barros+SA%22">Barros SA</searchLink>; Johnson & Johnson, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Somani+S%22">Somani S</searchLink>; Johnson & Johnson, Spring House, PA, USA.; Pinnacle Medicines, Doylestown, PA, USA.<br /><searchLink fieldCode="AU" term="%22Monshouwer+M%22">Monshouwer M</searchLink>; Johnson & Johnson, Beerse, Belgium.
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  Data: <searchLink fieldCode="JN" term="%22101590450%22">Dermatology and therapy</searchLink> [Dermatol Ther (Heidelb)] 2025 Sep; Vol. 15 (9), pp. 2495-2520. <i>Date of Electronic Publication: </i>2025 Jul 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Healthcare+Communications%22">Springer Healthcare Communications </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101590450 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2193-8210 (Print) <i>NLM ISO Abbreviation: </i>Dermatol Ther (Heidelb) <i>Subsets: </i>PubMed not MEDLINE
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