Human Medial Ganglionic Eminence Organoids Robustly Generate Parvalbumin Interneurons and Fast-Spiking Neurons and Reveal Migratory Deficits in SLC6A1 Deficient Interneurons.
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| Title: | Human Medial Ganglionic Eminence Organoids Robustly Generate Parvalbumin Interneurons and Fast-Spiking Neurons and Reveal Migratory Deficits in SLC6A1 Deficient Interneurons. |
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| Authors: | Varela MC; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; These authors contributed equally., Walker MP; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; These authors contributed equally., Bok J; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA., Crespo EL; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Thenstedt T; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Goldstein L; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Tidball AM; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI, USA., Yuan Y; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA., Isom LL; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA., Fu J; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA., Uhler M; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI, USA., Parent JM; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI, USA.; VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.; Lead contact. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 14. Date of Electronic Publication: 2025 Nov 14. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40631166 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Human Medial Ganglionic Eminence Organoids Robustly Generate Parvalbumin Interneurons and Fast-Spiking Neurons and Reveal Migratory Deficits in SLC6A1 Deficient Interneurons. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Varela+MC%22">Varela MC</searchLink>; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; These authors contributed equally.<br /><searchLink fieldCode="AU" term="%22Walker+MP%22">Walker MP</searchLink>; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; These authors contributed equally.<br /><searchLink fieldCode="AU" term="%22Bok+J%22">Bok J</searchLink>; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Crespo+EL%22">Crespo EL</searchLink>; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Thenstedt+T%22">Thenstedt T</searchLink>; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Goldstein+L%22">Goldstein L</searchLink>; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Tidball+AM%22">Tidball AM</searchLink>; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+Y%22">Yuan Y</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Isom+LL%22">Isom LL</searchLink>; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Fu+J%22">Fu J</searchLink>; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Uhler+M%22">Uhler M</searchLink>; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Parent+JM%22">Parent JM</searchLink>; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI, USA.; VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.; Lead contact. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Nov 14. <i>Date of Electronic Publication: </i>2025 Nov 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40631166 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/2025.07.01.662594 Languages: – Code: eng Text: English Titles: – TitleFull: Human Medial Ganglionic Eminence Organoids Robustly Generate Parvalbumin Interneurons and Fast-Spiking Neurons and Reveal Migratory Deficits in SLC6A1 Deficient Interneurons. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Varela MC – PersonEntity: Name: NameFull: Walker MP – PersonEntity: Name: NameFull: Bok J – PersonEntity: Name: NameFull: Crespo EL – PersonEntity: Name: NameFull: Thenstedt T – PersonEntity: Name: NameFull: Goldstein L – PersonEntity: Name: NameFull: Tidball AM – PersonEntity: Name: NameFull: Yuan Y – PersonEntity: Name: NameFull: Isom LL – PersonEntity: Name: NameFull: Fu J – PersonEntity: Name: NameFull: Uhler M – PersonEntity: Name: NameFull: Parent JM IsPartOfRelationships: – BibEntity: Dates: – D: 14 M: 11 Text: 2025 Nov 14 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2692-8205 Titles: – TitleFull: BioRxiv : the preprint server for biology Type: main |
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