Human Medial Ganglionic Eminence Organoids Robustly Generate Parvalbumin Interneurons and Fast-Spiking Neurons and Reveal Migratory Deficits in SLC6A1 Deficient Interneurons.
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| Title: | Human Medial Ganglionic Eminence Organoids Robustly Generate Parvalbumin Interneurons and Fast-Spiking Neurons and Reveal Migratory Deficits in SLC6A1 Deficient Interneurons. |
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| Authors: | Varela MC; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; These authors contributed equally., Walker MP; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; These authors contributed equally., Bok J; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA., Crespo EL; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Thenstedt T; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Goldstein L; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Tidball AM; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI, USA., Yuan Y; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA., Isom LL; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA., Fu J; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA., Uhler M; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI, USA., Parent JM; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.; Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI, USA.; VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.; Lead contact. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 14. Date of Electronic Publication: 2025 Nov 14. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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