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Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators.

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Title: Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators.
Authors: Bian Z; AbbVie Inc, North Chicago, Illinois 60064, United States., Schmidt RG; AbbVie Inc, North Chicago, Illinois 60064, United States., Wilson NS; AbbVie Inc, North Chicago, Illinois 60064, United States., Duignan DB; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Breinlinger E; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Dombrowski AW; AbbVie Inc, North Chicago, Illinois 60064, United States., Erdman P; AbbVie Inc, North Chicago, Illinois 60064, United States., Foley CM; AbbVie Inc, North Chicago, Illinois 60064, United States., Friedman M; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Gfesser GA; AbbVie Inc, North Chicago, Illinois 60064, United States., Goess CA; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Gomtsyan A; AbbVie Inc, North Chicago, Illinois 60064, United States., Judge RA; AbbVie Inc, North Chicago, Illinois 60064, United States., Kikuchi R; AbbVie Inc, North Chicago, Illinois 60064, United States., Koshman Y; AbbVie Inc, North Chicago, Illinois 60064, United States., Liu X; AbbVie Inc, North Chicago, Illinois 60064, United States., Longenecker KL; AbbVie Inc, North Chicago, Illinois 60064, United States., McClure A; AbbVie Inc, North Chicago, Illinois 60064, United States., Sippy K; AbbVie Inc, North Chicago, Illinois 60064, United States., Wetter JM; AbbVie Inc, North Chicago, Illinois 60064, United States., Stoffel R; AbbVie Inc, North Chicago, Illinois 60064, United States., Vasudevan A; AbbVie Inc, North Chicago, Illinois 60064, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Jul 24; Vol. 68 (14), pp. 14357-14383. Date of Electronic Publication: 2025 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Jul 24; Vol. 68 (14), pp. 14357-14383. <i>Date of Electronic Publication: </i>2025 Jul 09.
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