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Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties.

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Title: Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties.
Authors: Li R; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.; Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA 90033, USA., Hua Y; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15219, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Biomedical Engineering, University of Mississippi, University, MS 38677, USA., Zhang F; Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612, USA.; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92612, USA., Qian X; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.; Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA 90033, USA., Gong C; Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA 90033, USA., Wan X; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA., Waxman S; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15219, USA., Zeng Y; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA., Che Z; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA., Zhang J; Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA 90033, USA., Jin W; Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612, USA.; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92612, USA., Humayun MS; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.; Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA 90033, USA.; Allen and Charlotte Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90089, USA., Chen Z; Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612, USA.; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92612, USA., Sigal IA; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15219, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA., Zhou Q; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.; Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA 90033, USA.; Allen and Charlotte Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90089, USA.
Source: Science advances [Sci Adv] 2025 Jul 11; Vol. 11 (28), pp. eadp8631. Date of Electronic Publication: 2025 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.; Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA 90033, USA.<br /><searchLink fieldCode="AU" term="%22Hua+Y%22">Hua Y</searchLink>; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15219, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Biomedical Engineering, University of Mississippi, University, MS 38677, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612, USA.; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92612, USA.<br /><searchLink fieldCode="AU" term="%22Qian+X%22">Qian X</searchLink>; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.; Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA 90033, USA.<br /><searchLink fieldCode="AU" term="%22Gong+C%22">Gong C</searchLink>; Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA 90033, USA.<br /><searchLink fieldCode="AU" term="%22Wan+X%22">Wan X</searchLink>; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.<br /><searchLink fieldCode="AU" term="%22Waxman+S%22">Waxman S</searchLink>; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15219, USA.<br /><searchLink fieldCode="AU" term="%22Zeng+Y%22">Zeng Y</searchLink>; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.<br /><searchLink fieldCode="AU" term="%22Che+Z%22">Che Z</searchLink>; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA 90033, USA.<br /><searchLink fieldCode="AU" term="%22Jin+W%22">Jin W</searchLink>; Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612, USA.; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92612, USA.<br /><searchLink fieldCode="AU" term="%22Humayun+MS%22">Humayun MS</searchLink>; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.; Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA 90033, USA.; Allen and Charlotte Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90089, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612, USA.; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92612, USA.<br /><searchLink fieldCode="AU" term="%22Sigal+IA%22">Sigal IA</searchLink>; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15219, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+Q%22">Zhou Q</searchLink>; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.; Roski Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA 90033, USA.; Allen and Charlotte Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90089, USA.
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