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Clinical impact of pharmacogenetic risk variants in a large chinese cohort.

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Title: Clinical impact of pharmacogenetic risk variants in a large chinese cohort.
Authors: Wei CY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. nancy.wei324@gmail.com.; Core Laboratory of Neoantigen Analysis for Personalized Cancer Vaccine, Office of R&D, Taipei Medical University, Taipei, Taiwan. nancy.wei324@gmail.com., Wen MS; Division of Cardiology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; School of Medicine, Chang Gung University, Taoyuan, Taiwan., Cheng CK; Department of Neurology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Sheen YJ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan., Yao TC; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan., Lee SL; Department of Internal Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Tsai MF; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Li LH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen CH; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan., Fann CS; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Yang HC; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan., Huang YT; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.; Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan.; Department of Mathematics, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan., Chen HH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Liu YM; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Yeh EC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Peng YC; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Wang SJ; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chen SP; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Division of Translational Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Tsai MT; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Huo TI; Division of Basic Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Su CW; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of General Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Tarng DC; Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Clinical Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Huang CC; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Fuh JL; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Brain Research Center & School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lan KH; Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Liu YT; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Epilepsy, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lu CL; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan., Lee YC; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Neurology, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan., Huang YH; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; Healthcare and Services Center, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Li CP; Division of Clinical Skills Training, Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Therapeutic and Research Center of Pancreatic Cancer, Taipei Veterans General Hospital, Taipei, Taiwan., Wang YF; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Hsieh YC; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Chen YM; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Hsiao TH; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Lin CH; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Chen YJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Chen IC; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Mao CL; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Chang SJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Chang YL; Department of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan., Liao YJ; Department of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan., Lai CH; Department of Medicine and Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan., Lee WJ; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan., Tung H; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan., Yen TT; Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan., Yen HC; Division of Pediatric Genetics and Metabolism, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan., Chang JH; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan., Huang CY; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan., Chan L; Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Taipei Neuroscience Institute, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan., Lin YW; Department of Urology, School of Medicine, College of Medicine and TMU Research Center of Urology and Kidney (TMU-RCUK), Taipei Medical University, Taipei, Taiwan.; Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; International Master/PhD Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Hsiao BY; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan., Hu CJ; Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Lin YK; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan., Lin YF; Department of Medicine Research, Taipei Medical University Hospital, Taipei, Taiwan., Chang TC; Division of Colorectal Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of General Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Wu DC; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Internal Medicine, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan., Kan JY; Division of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Hsu CY; Sleep Medicine Center, Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Neurology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Chen SC; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Li CC; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Urology, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan., Huang CF; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Sheu CC; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Yang LJ; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Internal Medicine, Kaohsiung Municipal CiJin Hospital, Kaohsiung, Taiwan., Chen CH; Orthopaedic Research Center and Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital and Kaohsiung Medical University Hospital, Kaohsiung, Taiwan., Chen KM; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chang SM; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Liou MS; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Wang SP; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Lin KT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chuang HP; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen YJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Sin J; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen YT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chang CC; Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan., Kuo CF; Center for Artificial Intelligence in Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Department of Internal Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Lin JC; Division of Allergy Immunology and Rheumatology, Chang Gung Memorial Hospital, Chiayi, Taiwan., Kuo HC; Pediatric Internal Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taipei, Taiwan.; Chang Gung University College of Medicine, Kaohsiung, Taiwan., Chan TM; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Department of Internal Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Lee CW; Division of General Surgery, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan., Lai JH; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan., Luo SF; Department of Rheumatology, Allergy and Immunology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan., Cheng HT; Department of Gastroenterology and Hepatology, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan.; Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Lin LY; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan., Chang LC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Tsai CT; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Kao HL; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Yu JJ; Department of Internal Medicine, National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan., Jeng JS; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Neurology, National Taiwan University College of Medicine, Taipei, Taiwan., Chiu MC; Department of Internal Medicine, National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan., Hong TC; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Cancer Center, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan., Lu HJ; Division of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan., Su SC; Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Chu P; Nephrology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Li PF; Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Tsai CL; Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Tsai CK; Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Tang SE; Pulmonary Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Lin CM; Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Wu YF; Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Huang CY; Cardiovascular and Mitochondria Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan., Ling SZ; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan., Chang CC; Department of Laboratory Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien, Taiwan., Lin TK; Department of Dermatology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; School of Medicine, Tzu Chi University, Hualien, Taiwan., Hsiao SM; Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei, Taiwan.; Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, Taiwan.; Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan., Chang CH; Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, Taiwan.; Department of Orthopedic Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan., Chen CD; Department of Family Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan., Ma GC; Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan., Chang TY; Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan., Hwang JJ; Department of Cardiology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan., Lu CL; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.; Division of Nephrology, Department of Internal Medicine, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan., Kao KJ; Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan., Hung CF; Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan., Chen SS; Division of Urology, Taipei City Hospital Ren Ai Branch, Taipei, Taiwan.; University of Taipei, General Education Center, Taipei, Taiwan.; Department of Urology, College of Medicine and Shu-Tien Urological Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chen PY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan.; Clinical Trial Center, Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan., Tsui K; School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.; Department of Clinical Pathology, Cathay General Hospital, Taipei, Taiwan.; Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan., Chen YT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. chchen@ibms.sinica.edu.tw., Chien CC; School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. chiencmail@gmail.com.; Department of Anesthesiology, Cathay General Hospital, Taipei, Taiwan. chiencmail@gmail.com., Chiang HS; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan. a00001@mail.fjuh.fju.edu.tw.; Department of Urology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan. a00001@mail.fjuh.fju.edu.tw., Chiu YL; Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City, Taiwan. yenling.chiu@gmail.com.; Graduate Institute of Medicine and Graduate Program in Biomedical Informatics, Yuan Ze University, Taoyuan, Taiwan. yenling.chiu@gmail.com., Chen HC; Division of Rheumatology, Immunology and Allergy, Tri-Service General Hospital, Taipei, Taiwan. alex0624x@yahoo.com.tw., Kwok PY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Pui.Kwok@ucsf.edu.; Cardiovascular Research Institute, Institute for Human Genetics, and Department of Dermatology, University of California, San Francisco, CA, USA. Pui.Kwok@ucsf.edu.
Source: Nature communications [Nat Commun] 2025 Jul 09; Vol. 16 (1), pp. 6344. Date of Electronic Publication: 2025 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Clinical impact of pharmacogenetic risk variants in a large chinese cohort.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Wei+CY%22">Wei CY</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. nancy.wei324@gmail.com.; Core Laboratory of Neoantigen Analysis for Personalized Cancer Vaccine, Office of R&D, Taipei Medical University, Taipei, Taiwan. nancy.wei324@gmail.com.<br /><searchLink fieldCode="AU" term="%22Wen+MS%22">Wen MS</searchLink>; Division of Cardiology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.; School of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+CK%22">Cheng CK</searchLink>; Department of Neurology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sheen+YJ%22">Sheen YJ</searchLink>; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yao+TC%22">Yao TC</searchLink>; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+SL%22">Lee SL</searchLink>; Department of Internal Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+JY%22">Wu JY</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+MF%22">Tsai MF</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+LH%22">Li LH</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fann+CS%22">Fann CS</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+HC%22">Yang HC</searchLink>; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YT%22">Huang YT</searchLink>; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.; Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan.; Department of Mathematics, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+HH%22">Chen HH</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+YM%22">Liu YM</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+EC%22">Yeh EC</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Peng+YC%22">Peng YC</searchLink>; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+SJ%22">Wang SJ</searchLink>; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+SP%22">Chen SP</searchLink>; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Division of Translational Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+MT%22">Tsai MT</searchLink>; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huo+TI%22">Huo TI</searchLink>; Division of Basic Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Su+CW%22">Su CW</searchLink>; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of General Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tarng+DC%22">Tarng DC</searchLink>; Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Clinical Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CC%22">Huang CC</searchLink>; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fuh+JL%22">Fuh JL</searchLink>; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Brain Research Center & School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lan+KH%22">Lan KH</searchLink>; Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+YT%22">Liu YT</searchLink>; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Epilepsy, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+CL%22">Lu CL</searchLink>; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+YC%22">Lee YC</searchLink>; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Neurology, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YH%22">Huang YH</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; Healthcare and Services Center, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+CP%22">Li CP</searchLink>; Division of Clinical Skills Training, Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Therapeutic and Research Center of Pancreatic Cancer, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+YF%22">Wang YF</searchLink>; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+YC%22">Hsieh YC</searchLink>; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YM%22">Chen YM</searchLink>; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsiao+TH%22">Hsiao TH</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YJ%22">Chen YJ</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+IC%22">Chen IC</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Mao+CL%22">Mao CL</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+SJ%22">Chang SJ</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+YL%22">Chang YL</searchLink>; Department of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liao+YJ%22">Liao YJ</searchLink>; Department of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+CH%22">Lai CH</searchLink>; Department of Medicine and Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+WJ%22">Lee WJ</searchLink>; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tung+H%22">Tung H</searchLink>; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+TT%22">Yen TT</searchLink>; Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+HC%22">Yen HC</searchLink>; Division of Pediatric Genetics and Metabolism, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+JH%22">Chang JH</searchLink>; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CY%22">Huang CY</searchLink>; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chan+L%22">Chan L</searchLink>; Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Taipei Neuroscience Institute, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YW%22">Lin YW</searchLink>; Department of Urology, School of Medicine, College of Medicine and TMU Research Center of Urology and Kidney (TMU-RCUK), Taipei Medical University, Taipei, Taiwan.; Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; International Master/PhD Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsiao+BY%22">Hsiao BY</searchLink>; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hu+CJ%22">Hu CJ</searchLink>; Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YK%22">Lin YK</searchLink>; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YF%22">Lin YF</searchLink>; Department of Medicine Research, Taipei Medical University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+TC%22">Chang TC</searchLink>; Division of Colorectal Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Division of General Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+DC%22">Wu DC</searchLink>; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Internal Medicine, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kan+JY%22">Kan JY</searchLink>; Division of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+CY%22">Hsu CY</searchLink>; Sleep Medicine Center, Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Neurology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+SC%22">Chen SC</searchLink>; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+CC%22">Li CC</searchLink>; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Urology, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CF%22">Huang CF</searchLink>; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Faculty of Internal Medicine and Hepatitis Research Center, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sheu+CC%22">Sheu CC</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+LJ%22">Yang LJ</searchLink>; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Internal Medicine, Kaohsiung Municipal CiJin Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Orthopaedic Research Center and Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital and Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+KM%22">Chen KM</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+SM%22">Chang SM</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liou+MS%22">Liou MS</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+SP%22">Wang SP</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+KT%22">Lin KT</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chuang+HP%22">Chuang HP</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YJ%22">Chen YJ</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sin+J%22">Sin J</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YT%22">Chen YT</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CC%22">Chang CC</searchLink>; Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuo+CF%22">Kuo CF</searchLink>; Center for Artificial Intelligence in Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Department of Internal Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+JC%22">Lin JC</searchLink>; Division of Allergy Immunology and Rheumatology, Chang Gung Memorial Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuo+HC%22">Kuo HC</searchLink>; Pediatric Internal Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taipei, Taiwan.; Chang Gung University College of Medicine, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chan+TM%22">Chan TM</searchLink>; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Department of Internal Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+CW%22">Lee CW</searchLink>; Division of General Surgery, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+JH%22">Lai JH</searchLink>; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Luo+SF%22">Luo SF</searchLink>; Department of Rheumatology, Allergy and Immunology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+HT%22">Cheng HT</searchLink>; Department of Gastroenterology and Hepatology, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan.; Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+LY%22">Lin LY</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+LC%22">Chang LC</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+CT%22">Tsai CT</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kao+HL%22">Kao HL</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+JJ%22">Yu JJ</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jeng+JS%22">Jeng JS</searchLink>; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Neurology, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+MC%22">Chiu MC</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hong+TC%22">Hong TC</searchLink>; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Cancer Center, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+SF%22">Yang SF</searchLink>; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+HJ%22">Lu HJ</searchLink>; Division of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Su+SC%22">Su SC</searchLink>; Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chu+P%22">Chu P</searchLink>; Nephrology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+PF%22">Li PF</searchLink>; Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+CL%22">Tsai CL</searchLink>; Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+CK%22">Tsai CK</searchLink>; Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tang+SE%22">Tang SE</searchLink>; Pulmonary Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CM%22">Lin CM</searchLink>; Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+YF%22">Wu YF</searchLink>; Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CY%22">Huang CY</searchLink>; Cardiovascular and Mitochondria Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ling+SZ%22">Ling SZ</searchLink>; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CC%22">Chang CC</searchLink>; Department of Laboratory Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+TK%22">Lin TK</searchLink>; Department of Dermatology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; School of Medicine, Tzu Chi University, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsiao+SM%22">Hsiao SM</searchLink>; Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei, Taiwan.; Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, Taiwan.; Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CH%22">Chang CH</searchLink>; Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, Taiwan.; Department of Orthopedic Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CD%22">Chen CD</searchLink>; Department of Family Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ma+GC%22">Ma GC</searchLink>; Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+TY%22">Chang TY</searchLink>; Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hwang+JJ%22">Hwang JJ</searchLink>; Department of Cardiology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+CL%22">Lu CL</searchLink>; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.; Division of Nephrology, Department of Internal Medicine, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kao+KJ%22">Kao KJ</searchLink>; Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+CF%22">Hung CF</searchLink>; Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+SS%22">Chen SS</searchLink>; Division of Urology, Taipei City Hospital Ren Ai Branch, Taipei, Taiwan.; University of Taipei, General Education Center, Taipei, Taiwan.; Department of Urology, College of Medicine and Shu-Tien Urological Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+PY%22">Chen PY</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan.; Clinical Trial Center, Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsui+K%22">Tsui K</searchLink>; School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.; Department of Clinical Pathology, Cathay General Hospital, Taipei, Taiwan.; Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YT%22">Chen YT</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. chchen@ibms.sinica.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chien+CC%22">Chien CC</searchLink>; School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. chiencmail@gmail.com.; Department of Anesthesiology, Cathay General Hospital, Taipei, Taiwan. chiencmail@gmail.com.<br /><searchLink fieldCode="AU" term="%22Chiang+HS%22">Chiang HS</searchLink>; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan. a00001@mail.fjuh.fju.edu.tw.; Department of Urology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan. a00001@mail.fjuh.fju.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chiu+YL%22">Chiu YL</searchLink>; Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City, Taiwan. yenling.chiu@gmail.com.; Graduate Institute of Medicine and Graduate Program in Biomedical Informatics, Yuan Ze University, Taoyuan, Taiwan. yenling.chiu@gmail.com.<br /><searchLink fieldCode="AU" term="%22Chen+HC%22">Chen HC</searchLink>; Division of Rheumatology, Immunology and Allergy, Tri-Service General Hospital, Taipei, Taiwan. alex0624x@yahoo.com.tw.<br /><searchLink fieldCode="AU" term="%22Kwok+PY%22">Kwok PY</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Pui.Kwok@ucsf.edu.; Cardiovascular Research Institute, Institute for Human Genetics, and Department of Dermatology, University of California, San Francisco, CA, USA. Pui.Kwok@ucsf.edu.
– Name: TitleSource
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Jul 09; Vol. 16 (1), pp. 6344. <i>Date of Electronic Publication: </i>2025 Jul 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
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      – TitleFull: Clinical impact of pharmacogenetic risk variants in a large chinese cohort.
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            NameFull: Huo TI
      – PersonEntity:
          Name:
            NameFull: Su CW
      – PersonEntity:
          Name:
            NameFull: Tarng DC
      – PersonEntity:
          Name:
            NameFull: Huang CC
      – PersonEntity:
          Name:
            NameFull: Fuh JL
      – PersonEntity:
          Name:
            NameFull: Lan KH
      – PersonEntity:
          Name:
            NameFull: Liu YT
      – PersonEntity:
          Name:
            NameFull: Lu CL
      – PersonEntity:
          Name:
            NameFull: Lee YC
      – PersonEntity:
          Name:
            NameFull: Huang YH
      – PersonEntity:
          Name:
            NameFull: Li CP
      – PersonEntity:
          Name:
            NameFull: Wang YF
      – PersonEntity:
          Name:
            NameFull: Hsieh YC
      – PersonEntity:
          Name:
            NameFull: Chen YM
      – PersonEntity:
          Name:
            NameFull: Hsiao TH
      – PersonEntity:
          Name:
            NameFull: Lin CH
      – PersonEntity:
          Name:
            NameFull: Chen YJ
      – PersonEntity:
          Name:
            NameFull: Chen IC
      – PersonEntity:
          Name:
            NameFull: Mao CL
      – PersonEntity:
          Name:
            NameFull: Chang SJ
      – PersonEntity:
          Name:
            NameFull: Chang YL
      – PersonEntity:
          Name:
            NameFull: Liao YJ
      – PersonEntity:
          Name:
            NameFull: Lai CH
      – PersonEntity:
          Name:
            NameFull: Lee WJ
      – PersonEntity:
          Name:
            NameFull: Tung H
      – PersonEntity:
          Name:
            NameFull: Yen TT
      – PersonEntity:
          Name:
            NameFull: Yen HC
      – PersonEntity:
          Name:
            NameFull: Chang JH
      – PersonEntity:
          Name:
            NameFull: Huang CY
      – PersonEntity:
          Name:
            NameFull: Chan L
      – PersonEntity:
          Name:
            NameFull: Lin YW
      – PersonEntity:
          Name:
            NameFull: Hsiao BY
      – PersonEntity:
          Name:
            NameFull: Hu CJ
      – PersonEntity:
          Name:
            NameFull: Lin YK
      – PersonEntity:
          Name:
            NameFull: Lin YF
      – PersonEntity:
          Name:
            NameFull: Chang TC
      – PersonEntity:
          Name:
            NameFull: Wu DC
      – PersonEntity:
          Name:
            NameFull: Kan JY
      – PersonEntity:
          Name:
            NameFull: Hsu CY
      – PersonEntity:
          Name:
            NameFull: Chen SC
      – PersonEntity:
          Name:
            NameFull: Li CC
      – PersonEntity:
          Name:
            NameFull: Huang CF
      – PersonEntity:
          Name:
            NameFull: Sheu CC
      – PersonEntity:
          Name:
            NameFull: Yang LJ
      – PersonEntity:
          Name:
            NameFull: Chen CH
      – PersonEntity:
          Name:
            NameFull: Chen KM
      – PersonEntity:
          Name:
            NameFull: Chang SM
      – PersonEntity:
          Name:
            NameFull: Liou MS
      – PersonEntity:
          Name:
            NameFull: Wang SP
      – PersonEntity:
          Name:
            NameFull: Lin KT
      – PersonEntity:
          Name:
            NameFull: Chuang HP
      – PersonEntity:
          Name:
            NameFull: Chen YJ
      – PersonEntity:
          Name:
            NameFull: Sin J
      – PersonEntity:
          Name:
            NameFull: Chen YT
      – PersonEntity:
          Name:
            NameFull: Chang CC
      – PersonEntity:
          Name:
            NameFull: Kuo CF
      – PersonEntity:
          Name:
            NameFull: Lin JC
      – PersonEntity:
          Name:
            NameFull: Kuo HC
      – PersonEntity:
          Name:
            NameFull: Chan TM
      – PersonEntity:
          Name:
            NameFull: Lee CW
      – PersonEntity:
          Name:
            NameFull: Lai JH
      – PersonEntity:
          Name:
            NameFull: Luo SF
      – PersonEntity:
          Name:
            NameFull: Cheng HT
      – PersonEntity:
          Name:
            NameFull: Lin LY
      – PersonEntity:
          Name:
            NameFull: Chang LC
      – PersonEntity:
          Name:
            NameFull: Tsai CT
      – PersonEntity:
          Name:
            NameFull: Kao HL
      – PersonEntity:
          Name:
            NameFull: Yu JJ
      – PersonEntity:
          Name:
            NameFull: Jeng JS
      – PersonEntity:
          Name:
            NameFull: Chiu MC
      – PersonEntity:
          Name:
            NameFull: Hong TC
      – PersonEntity:
          Name:
            NameFull: Yang SF
      – PersonEntity:
          Name:
            NameFull: Lu HJ
      – PersonEntity:
          Name:
            NameFull: Su SC
      – PersonEntity:
          Name:
            NameFull: Chu P
      – PersonEntity:
          Name:
            NameFull: Li PF
      – PersonEntity:
          Name:
            NameFull: Tsai CL
      – PersonEntity:
          Name:
            NameFull: Tsai CK
      – PersonEntity:
          Name:
            NameFull: Tang SE
      – PersonEntity:
          Name:
            NameFull: Lin CM
      – PersonEntity:
          Name:
            NameFull: Wu YF
      – PersonEntity:
          Name:
            NameFull: Huang CY
      – PersonEntity:
          Name:
            NameFull: Ling SZ
      – PersonEntity:
          Name:
            NameFull: Chang CC
      – PersonEntity:
          Name:
            NameFull: Lin TK
      – PersonEntity:
          Name:
            NameFull: Hsiao SM
      – PersonEntity:
          Name:
            NameFull: Chang CH
      – PersonEntity:
          Name:
            NameFull: Chen CD
      – PersonEntity:
          Name:
            NameFull: Ma GC
      – PersonEntity:
          Name:
            NameFull: Chang TY
      – PersonEntity:
          Name:
            NameFull: Hwang JJ
      – PersonEntity:
          Name:
            NameFull: Lu CL
      – PersonEntity:
          Name:
            NameFull: Kao KJ
      – PersonEntity:
          Name:
            NameFull: Hung CF
      – PersonEntity:
          Name:
            NameFull: Chen SS
      – PersonEntity:
          Name:
            NameFull: Chen PY
      – PersonEntity:
          Name:
            NameFull: Tsui K
      – PersonEntity:
          Name:
            NameFull: Chen YT
      – PersonEntity:
          Name:
            NameFull: Chen CH
      – PersonEntity:
          Name:
            NameFull: Chien CC
      – PersonEntity:
          Name:
            NameFull: Chiang HS
      – PersonEntity:
          Name:
            NameFull: Chiu YL
      – PersonEntity:
          Name:
            NameFull: Chen HC
      – PersonEntity:
          Name:
            NameFull: Kwok PY
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 09
              M: 07
              Text: 2025 Jul 09
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 16
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1