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Targeting Tumor-Infiltrating Immune Cells for Targeted Alpha Therapy in Gliomas: Optimization of [225Ac]Ac-DOTA-αCD11b Dosing through PET Imaging.

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Title: Targeting Tumor-Infiltrating Immune Cells for Targeted Alpha Therapy in Gliomas: Optimization of [225Ac]Ac-DOTA-αCD11b Dosing through PET Imaging.
Authors: Jaswal AP; Department of Neurological Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Josefsson A; Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Cortez AG; Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Bhise A; Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Li B; Division of Laboratory Animal Resources, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Sneiderman CT; Department of Neurological Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Vincze SR; Department of Neurological Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Nisnboym M; Department of Neurological Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel., Latoche JD; Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Day KE; Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Edinger RS; Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Raphael I; Department of Neurological Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Rigatti LH; Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Division of Laboratory Animal Resources, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Edward WB; Department of Biochemistry, University of Missouri, Columbia, Missouri., Kohanbash G; Department of Neurological Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania., Nedrow JR; Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2025 Dec 02; Vol. 24 (12), pp. 1948-1958.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
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  Data: Targeting Tumor-Infiltrating Immune Cells for Targeted Alpha Therapy in Gliomas: Optimization of [225Ac]Ac-DOTA-αCD11b Dosing through PET Imaging.
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