The efficacy of adjunctive Garcinia mangostana Linn. (mangosteen) pericarp extract for bipolar depression: 24-week randomised controlled trial.

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Title: The efficacy of adjunctive Garcinia mangostana Linn. (mangosteen) pericarp extract for bipolar depression: 24-week randomised controlled trial.
Authors: Dean OM; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Australia., Cotton SM; Orygen Ltd, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.; Centre of Youth Mental Health, The University of Melbourne, Parkville, Australia.; School of Psychological Sciences, Monash University, Clayton, Australia.; Turner Institute for Brain and Mind, Clayton, Australia., Ashton MM; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia., Turner A; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia., Saunders L; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia., Ng CH; School of Psychological Sciences, Monash University, Clayton, Australia.; Department of Psychiatry University of Melbourne, The Melbourne Clinic, Professorial Unit, Richmond, Australia., Hopwood M; Department of Psychiatry University of Melbourne, Albert Road Clinic, Melbourne, Australia., Dodd S; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.; Centre of Youth Mental Health, The University of Melbourne, Parkville, Australia., Khoo JP; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.; Faculty of Medicine, The University of Queensland, Brisbane, Australia., Walker AJ; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia., Chatterton ML; Deakin University, Institute for Health Transformation, Geelong, Australia., Kavanagh BE; Deakin Rural Health, School of Medicine, Deakin University, Warrnambool, Australia., Nadjidai SE; Department of Psychiatry University of Melbourne, The Melbourne Clinic, Professorial Unit, Richmond, Australia., Lo Monaco SL; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia., Harvey BH; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.; Center of Excellence for Pharmaceutical Sciences, School of Pharmacy, North-West University, Potchefstroom, South Africa.; MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Malhi GS; Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, Australia.; CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, St. Leonards, Australia.; Department of Psychiatry, University of Oxford, Oxford, UK., Brown E; Orygen Ltd, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.; Centre of Youth Mental Health, The University of Melbourne, Parkville, Australia., Skvarc DR; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia., Diao D; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia., Jacka FN; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia., Sarris J; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.; NICM Health Research Institute, Western Sydney University, Westmead, Australia.; Centre for Mental Health, Swinburne University, Melbourne, Australia., Dowling NL; Department of Psychiatry University of Melbourne, The Melbourne Clinic, Professorial Unit, Richmond, Australia., Berk M; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.; Centre of Youth Mental Health, The University of Melbourne, Parkville, Australia.; Department of Psychiatry University of Melbourne, The Melbourne Clinic, Professorial Unit, Richmond, Australia.
Source: The British journal of psychiatry : the journal of mental science [Br J Psychiatry] 2025 Dec; Vol. 227 (6), pp. 854-863. Date of Electronic Publication: 2025 Jul 10.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Cambridge University Press Country of Publication: England NLM ID: 0342367 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-1465 (Electronic) Linking ISSN: 00071250 NLM ISO Abbreviation: Br J Psychiatry Subsets: MEDLINE
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  Data: The efficacy of adjunctive Garcinia mangostana Linn. (mangosteen) pericarp extract for bipolar depression: 24-week randomised controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Dean+OM%22">Dean OM</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Cotton+SM%22">Cotton SM</searchLink>; Orygen Ltd, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.; Centre of Youth Mental Health, The University of Melbourne, Parkville, Australia.; School of Psychological Sciences, Monash University, Clayton, Australia.; Turner Institute for Brain and Mind, Clayton, Australia.<br /><searchLink fieldCode="AU" term="%22Ashton+MM%22">Ashton MM</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Turner+A%22">Turner A</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Saunders+L%22">Saunders L</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Ng+CH%22">Ng CH</searchLink>; School of Psychological Sciences, Monash University, Clayton, Australia.; Department of Psychiatry University of Melbourne, The Melbourne Clinic, Professorial Unit, Richmond, Australia.<br /><searchLink fieldCode="AU" term="%22Hopwood+M%22">Hopwood M</searchLink>; Department of Psychiatry University of Melbourne, Albert Road Clinic, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Dodd+S%22">Dodd S</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.; Centre of Youth Mental Health, The University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Khoo+JP%22">Khoo JP</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.; Faculty of Medicine, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Walker+AJ%22">Walker AJ</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Chatterton+ML%22">Chatterton ML</searchLink>; Deakin University, Institute for Health Transformation, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Kavanagh+BE%22">Kavanagh BE</searchLink>; Deakin Rural Health, School of Medicine, Deakin University, Warrnambool, Australia.<br /><searchLink fieldCode="AU" term="%22Nadjidai+SE%22">Nadjidai SE</searchLink>; Department of Psychiatry University of Melbourne, The Melbourne Clinic, Professorial Unit, Richmond, Australia.<br /><searchLink fieldCode="AU" term="%22Lo+Monaco+SL%22">Lo Monaco SL</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Harvey+BH%22">Harvey BH</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.; Center of Excellence for Pharmaceutical Sciences, School of Pharmacy, North-West University, Potchefstroom, South Africa.; MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Malhi+GS%22">Malhi GS</searchLink>; Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, Australia.; CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, St. Leonards, Australia.; Department of Psychiatry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Brown+E%22">Brown E</searchLink>; Orygen Ltd, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.; Centre of Youth Mental Health, The University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Skvarc+DR%22">Skvarc DR</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Diao+D%22">Diao D</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Jacka+FN%22">Jacka FN</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Sarris+J%22">Sarris J</searchLink>; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.; NICM Health Research Institute, Western Sydney University, Westmead, Australia.; Centre for Mental Health, Swinburne University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Dowling+NL%22">Dowling NL</searchLink>; Department of Psychiatry University of Melbourne, The Melbourne Clinic, Professorial Unit, Richmond, Australia.<br /><searchLink fieldCode="AU" term="%22Berk+M%22">Berk M</searchLink>; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.; Centre of Youth Mental Health, The University of Melbourne, Parkville, Australia.; Department of Psychiatry University of Melbourne, The Melbourne Clinic, Professorial Unit, Richmond, Australia.
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  Data: <searchLink fieldCode="JN" term="%220342367%22">The British journal of psychiatry : the journal of mental science</searchLink> [Br J Psychiatry] 2025 Dec; Vol. 227 (6), pp. 854-863. <i>Date of Electronic Publication: </i>2025 Jul 10.
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