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Age-dependent impairment of cardiac function and physical performance in male mice with diet-induced obesity.

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Title: Age-dependent impairment of cardiac function and physical performance in male mice with diet-induced obesity.
Authors: Baumgarten P; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany., Kamp J; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany.; Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Augustenburger Platz 1, 13353, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Charitéplatz 1, 10117, Germany.; Deutsches Herzzentrum Der Charité (DHZC), Institute of Computer-Assisted Cardiovascular Medicine, Berlin, Augustenburger Platz 1, 13353, Germany., Hegemann N; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany.; Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Augustenburger Platz 1, 13353, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Charitéplatz 1, 10117, Germany.; Deutsches Herzzentrum Der Charité (DHZC), Institute of Computer-Assisted Cardiovascular Medicine, Berlin, Augustenburger Platz 1, 13353, Germany., Deubel S; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany., Berndt N; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Charitéplatz 1, 10117, Germany.; Deutsches Herzzentrum Der Charité (DHZC), Institute of Computer-Assisted Cardiovascular Medicine, Berlin, Augustenburger Platz 1, 13353, Germany., Grune J; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany.; Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Augustenburger Platz 1, 13353, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Charitéplatz 1, 10117, Germany.; Deutsches Herzzentrum Der Charité (DHZC), Institute of Computer-Assisted Cardiovascular Medicine, Berlin, Augustenburger Platz 1, 13353, Germany., Kuebler WM; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany.; Deutsches Herzzentrum Der Charité (DHZC), Institute of Computer-Assisted Cardiovascular Medicine, Berlin, Augustenburger Platz 1, 13353, Germany.; German Center for Lung Research (DZL)M, Associated Partner Site Berlin, Berlin, Germany.; Keenan Research Centre, St. Michael´S Hospital, Toronto, ON, Canada.; Departments of Physiology and Surgery, University of Toronto, Toronto, ON, Canada., Axelrod CL; Integrated Physiology and Molecular Medicine, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Kirwan JP; Integrated Physiology and Molecular Medicine, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Höhn A; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.; German Center for Diabetes Research (DZD) Ingoldstadter Landstraße 1, Munich-Neuherberg, 85764, Germany., Heider S; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.; German Center for Diabetes Research (DZD) Ingoldstadter Landstraße 1, Munich-Neuherberg, 85764, Germany., Ott C; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany., Grune T; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany. scientific.director@dife.de.; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany. scientific.director@dife.de.; German Center for Diabetes Research (DZD) Ingoldstadter Landstraße 1, Munich-Neuherberg, 85764, Germany. scientific.director@dife.de.; Institute of Nutritional Science, University of Potsdam, Potsdam, 14469, Germany. scientific.director@dife.de.; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, 1090, Austria. scientific.director@dife.de.
Source: GeroScience [Geroscience] 2026 Apr; Vol. 48 (2), pp. 2295-2309. Date of Electronic Publication: 2025 Jul 10.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Age-dependent impairment of cardiac function and physical performance in male mice with diet-induced obesity.
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  Data: <searchLink fieldCode="AU" term="%22Baumgarten+P%22">Baumgarten P</searchLink>; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany.<br /><searchLink fieldCode="AU" term="%22Kamp+J%22">Kamp J</searchLink>; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany.; Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Augustenburger Platz 1, 13353, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Charitéplatz 1, 10117, Germany.; Deutsches Herzzentrum Der Charité (DHZC), Institute of Computer-Assisted Cardiovascular Medicine, Berlin, Augustenburger Platz 1, 13353, Germany.<br /><searchLink fieldCode="AU" term="%22Hegemann+N%22">Hegemann N</searchLink>; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany.; Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Augustenburger Platz 1, 13353, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Charitéplatz 1, 10117, Germany.; Deutsches Herzzentrum Der Charité (DHZC), Institute of Computer-Assisted Cardiovascular Medicine, Berlin, Augustenburger Platz 1, 13353, Germany.<br /><searchLink fieldCode="AU" term="%22Deubel+S%22">Deubel S</searchLink>; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.<br /><searchLink fieldCode="AU" term="%22Berndt+N%22">Berndt N</searchLink>; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Charitéplatz 1, 10117, Germany.; Deutsches Herzzentrum Der Charité (DHZC), Institute of Computer-Assisted Cardiovascular Medicine, Berlin, Augustenburger Platz 1, 13353, Germany.<br /><searchLink fieldCode="AU" term="%22Grune+J%22">Grune J</searchLink>; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany.; Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Augustenburger Platz 1, 13353, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Charitéplatz 1, 10117, Germany.; Deutsches Herzzentrum Der Charité (DHZC), Institute of Computer-Assisted Cardiovascular Medicine, Berlin, Augustenburger Platz 1, 13353, Germany.<br /><searchLink fieldCode="AU" term="%22Kuebler+WM%22">Kuebler WM</searchLink>; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany.; Deutsches Herzzentrum Der Charité (DHZC), Institute of Computer-Assisted Cardiovascular Medicine, Berlin, Augustenburger Platz 1, 13353, Germany.; German Center for Lung Research (DZL)M, Associated Partner Site Berlin, Berlin, Germany.; Keenan Research Centre, St. Michael´S Hospital, Toronto, ON, Canada.; Departments of Physiology and Surgery, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Axelrod+CL%22">Axelrod CL</searchLink>; Integrated Physiology and Molecular Medicine, Pennington Biomedical Research Center, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22Kirwan+JP%22">Kirwan JP</searchLink>; Integrated Physiology and Molecular Medicine, Pennington Biomedical Research Center, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22Höhn+A%22">Höhn A</searchLink>; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.; German Center for Diabetes Research (DZD) Ingoldstadter Landstraße 1, Munich-Neuherberg, 85764, Germany.<br /><searchLink fieldCode="AU" term="%22Heider+S%22">Heider S</searchLink>; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.; German Center for Diabetes Research (DZD) Ingoldstadter Landstraße 1, Munich-Neuherberg, 85764, Germany.<br /><searchLink fieldCode="AU" term="%22Ott+C%22">Ott C</searchLink>; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany.; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany.<br /><searchLink fieldCode="AU" term="%22Grune+T%22">Grune T</searchLink>; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Arthur-Scheunert-Allee 114-116, 14585, Germany. scientific.director@dife.de.; German Center for Cardiovascular Research (DZHK), Berlin, Partner Site Berlin, Potsdamer Straße 58, Germany. scientific.director@dife.de.; German Center for Diabetes Research (DZD) Ingoldstadter Landstraße 1, Munich-Neuherberg, 85764, Germany. scientific.director@dife.de.; Institute of Nutritional Science, University of Potsdam, Potsdam, 14469, Germany. scientific.director@dife.de.; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, 1090, Austria. scientific.director@dife.de.
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