Selective expansion of TCF7-expressing tumor-reactive T cell subpopulations during ovarian tumor-infiltrating T cell production ex vivo.

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Title: Selective expansion of TCF7-expressing tumor-reactive T cell subpopulations during ovarian tumor-infiltrating T cell production ex vivo.
Authors: Liu D; Clinical and Translational Research Center, Department of Biobank, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 201204, China.; Shanghai Immune Therapy Institute, New Cornerstone Science Laboratory, Shanghai Jiao Tong University School of Medicine-Affiliated Renji Hospital, Shanghai, 200127, China., Zhang T; Shanghai Immune Therapy Institute, New Cornerstone Science Laboratory, Shanghai Jiao Tong University School of Medicine-Affiliated Renji Hospital, Shanghai, 200127, China., Sun Q; Institute for Immunology, Tsinghua University, Beijing, 100084, China., Cai D; Clinical and Translational Research Center, Department of Biobank, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 201204, China., Lou Y; Shanghai Immune Therapy Institute, New Cornerstone Science Laboratory, Shanghai Jiao Tong University School of Medicine-Affiliated Renji Hospital, Shanghai, 200127, China., Wang G; Shanghai Immune Therapy Institute, New Cornerstone Science Laboratory, Shanghai Jiao Tong University School of Medicine-Affiliated Renji Hospital, Shanghai, 200127, China.; School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China., Xie B; Institute for Immunology, Tsinghua University, Beijing, 100084, China., Zhu Y; Shanghai Immune Therapy Institute, New Cornerstone Science Laboratory, Shanghai Jiao Tong University School of Medicine-Affiliated Renji Hospital, Shanghai, 200127, China., Wang C; Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China., Lu Z; Clinical and Translational Research Center, Department of Biobank, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 201204, China., Liu C; Clinical and Translational Research Center, Department of Biobank, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 201204, China., Li Y; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China., Zhang X; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China., He T; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China., Hao J; Shanghai Immune Therapy Institute, New Cornerstone Science Laboratory, Shanghai Jiao Tong University School of Medicine-Affiliated Renji Hospital, Shanghai, 200127, China., Guo X; Shanghai Immune Therapy Institute, New Cornerstone Science Laboratory, Shanghai Jiao Tong University School of Medicine-Affiliated Renji Hospital, Shanghai, 200127, China., Li J; Institute for Immunology, Tsinghua University, Beijing, 100084, China., Xi X; Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China., Ni L; Institute for Immunology, Tsinghua University, Beijing, 100084, China., Guo H; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China. bysyghy@163.com., Ge J; Westlake University School of Medicine, Hangzhou, 310024, China. gejing@westlake.edu.cn., Jin L; Clinical and Translational Research Center, Department of Biobank, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 201204, China. jinlp01@163.com.; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, 200080, China. jinlp01@163.com., Dong C; Shanghai Immune Therapy Institute, New Cornerstone Science Laboratory, Shanghai Jiao Tong University School of Medicine-Affiliated Renji Hospital, Shanghai, 200127, China. dongchen@westlake.edu.cn.; Westlake University School of Medicine, Hangzhou, 310024, China. dongchen@westlake.edu.cn.
Source: Science China. Life sciences [Sci China Life Sci] 2025 Oct; Vol. 68 (10), pp. 2891-2907. Date of Electronic Publication: 2025 Jul 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Science China Press, co-published with Springer Country of Publication: China NLM ID: 101529880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1869-1889 (Electronic) Linking ISSN: 16747305 NLM ISO Abbreviation: Sci China Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1869-1889
DOI:10.1007/s11427-025-2958-3