Metformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
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| Title: | Metformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol. |
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| Authors: | Gillessen S; Institute of Oncology of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Università della Svizzera Italiana, Faculty of Biosciences, Lugano, Switzerland; Swiss Group for Clinical Cancer Research, Bern, Switzerland. Electronic address: silke.gillessen@eoc.ch., Murphy L; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., James ND; The Institute of Cancer Research and The Royal Marsden Hospital, London, UK., Sachdeva A; Division of Cancer Sciences, University of Manchester, Manchester, UK; The Christie Hospital NHS Foundation Trust, Manchester, UK., El-Taji O; Division of Cancer Sciences, University of Manchester, Manchester, UK; The Christie Hospital NHS Foundation Trust, Manchester, UK; Department of Urology, Salford Royal Hospital, Manchester, UK., Abdel-Aty H; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK; The Institute of Cancer Research and The Royal Marsden Hospital, London, UK., Adler AI; Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK., Amos C; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Attard G; University College London Cancer Institute, London, UK; University College London Hospitals, London, UK., Varughese M; Royal Devon University Hospitals NHS Foundation Trust & University of Exeter, Exeter, UK., Gale J; Queen Alexandra Hospital, Portsmouth, UK., Brown S; Oncology, Airedale General Hospital, Keighley, UK., Srihari N; Royal Shrewsbury Hospital, Shrewsbury, UK., Birtle AJ; Rosemere Cancer Centre, Lancashire Teaching Hospitals, Preston UK; University of Manchester, Manchester, UK; University of Central Lancashire, Preston, UK., Brown M; Division of Cancer Sciences, University of Manchester, Manchester, UK., Chan K; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Chowdhury S; Guy's and St Thomas' NHS Foundation Trust, London, UK., Cross W; St James's University Hospital, Leeds, UK., Dearnaley DP; The Institute of Cancer Research and The Royal Marsden Hospital, London, UK; Royal Marsden NHS Foundation Trust, London, UK., Din O; Weston Park Cancer Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Dutey-Magni P; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Gilbert DC; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Gilson C; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK; The Institute of Cancer Research and The Royal Marsden Hospital, London, UK., Gray S; Division of Cancer Sciences, University of Manchester, Manchester, UK; The Christie Hospital NHS Foundation Trust, Manchester, UK; Department of Urology, Salford Royal Hospital, Manchester, UK., Grist E; University College London Cancer Institute, London, UK., Hofmann U; Calderdale and Huddersfield NHS Trust, Halifax, UK., Hudson AM; The Christie Hospital NHS Foundation Trust, Manchester, UK., Jain Y; The Christie Hospital NHS Foundation Trust, Manchester, UK., Jeyasangar G; Department of Oncology, Airedale General Hospital NHS Foundation Trust, Keighley, UK., Jones R; School of Cancer Sciences, University of Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK., Kayani M; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Langley RE; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Malik Z; The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK., Mason MD; School of Medicine, Cardiff University, Cardiff, UK., Matheson D; Faculty of education Health and Wellbeing, University of Wolverhampton, Walsall, UK., McAlpine C; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Macnair A; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Millman R; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Murphy C; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Padden-Modi M; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK; The Institute of Cancer Research and The Royal Marsden Hospital, London, UK., Parikh O; Royal Blackburn Hospital, East Lancashire Hospitals NHS Trust, Blackburn, UK., Parker C; Royal Marsden Hospital and Institute of Cancer Research, Sutton, UK., Rush H; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK; Guy's and St Thomas' NHS Foundation Trust, London, UK., Russell M; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Srinivasan R; Department of Oncology, Royal Devon & Exeter Hospital, Exeter, UK., Sundar S; Nottingham University Hospitals NHS Trust, Nottingham, UK., Tanguay JS; Velindre Cancer Centre, Velindre University NHS Trust, Cardiff, UK., Turco F; Institute of Oncology of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Swiss Group for Clinical Cancer Research, Bern, Switzerland., Williams P; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Sydes MR; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Parmar MKB; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Brown LC; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Clarke NW; Division of Cancer Sciences, University of Manchester, Manchester, UK; The Christie Hospital NHS Foundation Trust, Manchester, UK; Department of Urology, Salford Royal Hospital, Manchester, UK. |
| Corporate Authors: | STAMPEDE investigators |
| Source: | The Lancet. Oncology [Lancet Oncol] 2025 Aug; Vol. 26 (8), pp. 1018-1030. Date of Electronic Publication: 2025 Jul 07. |
| Publication Type: | Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40639383 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Metformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Gillessen+S%22">Gillessen S</searchLink>; Institute of Oncology of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Università della Svizzera Italiana, Faculty of Biosciences, Lugano, Switzerland; Swiss Group for Clinical Cancer Research, Bern, Switzerland. Electronic address: silke.gillessen@eoc.ch.<br /><searchLink fieldCode="AU" term="%22Murphy+L%22">Murphy L</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22James+ND%22">James ND</searchLink>; The Institute of Cancer Research and The Royal Marsden Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Sachdeva+A%22">Sachdeva A</searchLink>; Division of Cancer Sciences, University of Manchester, Manchester, UK; The Christie Hospital NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22El-Taji+O%22">El-Taji O</searchLink>; Division of Cancer Sciences, University of Manchester, Manchester, UK; The Christie Hospital NHS Foundation Trust, Manchester, UK; Department of Urology, Salford Royal Hospital, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Abdel-Aty+H%22">Abdel-Aty H</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK; The Institute of Cancer Research and The Royal Marsden Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Adler+AI%22">Adler AI</searchLink>; Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Amos+C%22">Amos C</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Attard+G%22">Attard G</searchLink>; University College London Cancer Institute, London, UK; University College London Hospitals, London, UK.<br /><searchLink fieldCode="AU" term="%22Varughese+M%22">Varughese M</searchLink>; Royal Devon University Hospitals NHS Foundation Trust & University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Gale+J%22">Gale J</searchLink>; Queen Alexandra Hospital, Portsmouth, UK.<br /><searchLink fieldCode="AU" term="%22Brown+S%22">Brown S</searchLink>; Oncology, Airedale General Hospital, Keighley, UK.<br /><searchLink fieldCode="AU" term="%22Srihari+N%22">Srihari N</searchLink>; Royal Shrewsbury Hospital, Shrewsbury, UK.<br /><searchLink fieldCode="AU" term="%22Birtle+AJ%22">Birtle AJ</searchLink>; Rosemere Cancer Centre, Lancashire Teaching Hospitals, Preston UK; University of Manchester, Manchester, UK; University of Central Lancashire, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Brown+M%22">Brown M</searchLink>; Division of Cancer Sciences, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Chan+K%22">Chan K</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Chowdhury+S%22">Chowdhury S</searchLink>; Guy's and St Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Cross+W%22">Cross W</searchLink>; St James's University Hospital, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Dearnaley+DP%22">Dearnaley DP</searchLink>; The Institute of Cancer Research and The Royal Marsden Hospital, London, UK; Royal Marsden NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Din+O%22">Din O</searchLink>; Weston Park Cancer Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Dutey-Magni+P%22">Dutey-Magni P</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Gilbert+DC%22">Gilbert DC</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Gilson+C%22">Gilson C</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK; The Institute of Cancer Research and The Royal Marsden Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Gray+S%22">Gray S</searchLink>; Division of Cancer Sciences, University of Manchester, Manchester, UK; The Christie Hospital NHS Foundation Trust, Manchester, UK; Department of Urology, Salford Royal Hospital, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Grist+E%22">Grist E</searchLink>; University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Hofmann+U%22">Hofmann U</searchLink>; Calderdale and Huddersfield NHS Trust, Halifax, UK.<br /><searchLink fieldCode="AU" term="%22Hudson+AM%22">Hudson AM</searchLink>; The Christie Hospital NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Jain+Y%22">Jain Y</searchLink>; The Christie Hospital NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Jeyasangar+G%22">Jeyasangar G</searchLink>; Department of Oncology, Airedale General Hospital NHS Foundation Trust, Keighley, UK.<br /><searchLink fieldCode="AU" term="%22Jones+R%22">Jones R</searchLink>; School of Cancer Sciences, University of Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Kayani+M%22">Kayani M</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Langley+RE%22">Langley RE</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Malik+Z%22">Malik Z</searchLink>; The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Mason+MD%22">Mason MD</searchLink>; School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Matheson+D%22">Matheson D</searchLink>; Faculty of education Health and Wellbeing, University of Wolverhampton, Walsall, UK.<br /><searchLink fieldCode="AU" term="%22McAlpine+C%22">McAlpine C</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Macnair+A%22">Macnair A</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Millman+R%22">Millman R</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Murphy+C%22">Murphy C</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Padden-Modi+M%22">Padden-Modi M</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK; The Institute of Cancer Research and The Royal Marsden Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Parikh+O%22">Parikh O</searchLink>; Royal Blackburn Hospital, East Lancashire Hospitals NHS Trust, Blackburn, UK.<br /><searchLink fieldCode="AU" term="%22Parker+C%22">Parker C</searchLink>; Royal Marsden Hospital and Institute of Cancer Research, Sutton, UK.<br /><searchLink fieldCode="AU" term="%22Rush+H%22">Rush H</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK; Guy's and St Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Russell+M%22">Russell M</searchLink>; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Srinivasan+R%22">Srinivasan R</searchLink>; Department of Oncology, Royal Devon & Exeter Hospital, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Sundar+S%22">Sundar S</searchLink>; Nottingham University Hospitals NHS Trust, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Tanguay+JS%22">Tanguay JS</searchLink>; Velindre Cancer Centre, Velindre University NHS Trust, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Turco+F%22">Turco F</searchLink>; Institute of Oncology of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Swiss Group for Clinical Cancer Research, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Williams+P%22">Williams P</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sydes+MR%22">Sydes MR</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Parmar+MKB%22">Parmar MKB</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Brown+LC%22">Brown LC</searchLink>; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Clarke+NW%22">Clarke NW</searchLink>; Division of Cancer Sciences, University of Manchester, Manchester, UK; The Christie Hospital NHS Foundation Trust, Manchester, UK; Department of Urology, Salford Royal Hospital, Manchester, UK. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22STAMPEDE+investigators%22">STAMPEDE investigators</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100957246%22">The Lancet. Oncology</searchLink> [Lancet Oncol] 2025 Aug; Vol. 26 (8), pp. 1018-1030. <i>Date of Electronic Publication: </i>2025 Jul 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lancet+Pub%2E+Group%22">Lancet Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100957246 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-5488 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214702045%22">14702045 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Oncol <i>Subsets: </i>MEDLINE |
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