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Targeting mTORC2 in lung squamous cell carcinoma improves anti-tumor immunity through the PSGL-1-VISTA axis.

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Title: Targeting mTORC2 in lung squamous cell carcinoma improves anti-tumor immunity through the PSGL-1-VISTA axis.
Authors: Ngwa VM; Department of Medicine, Division of Rheumatology, Vanderbilt University Medical Center, Nashville, TN, USA., Hwang Y; Department of Medicine, Division of Rheumatology, Vanderbilt University Medical Center, Nashville, TN, USA., Song W; Department of Medicine, Division of Rheumatology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Edwards DN; Department of Medicine, Division of Rheumatology, Vanderbilt University Medical Center, Nashville, TN, USA., Chen J; Department of Medicine, Division of Rheumatology, Vanderbilt University Medical Center, Nashville, TN, USA. jin.chen@vumc.org.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. jin.chen@vumc.org.; Tennessee Valley Healthcare System, Department of Veterans Affairs, Nashville, TN, USA. jin.chen@vumc.org.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. jin.chen@vumc.org.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA. jin.chen@vumc.org.
Source: Cancer gene therapy [Cancer Gene Ther] 2025 Aug; Vol. 32 (8), pp. 899-910. Date of Electronic Publication: 2025 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9432230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5500 (Electronic) Linking ISSN: 09291903 NLM ISO Abbreviation: Cancer Gene Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5500
DOI:10.1038/s41417-025-00934-4