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Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome.

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Title: Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome.
Authors: Wang X; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.; Querrey Simpson Institute for Regenerative Engineering at Northwestern University, Northwestern University, Chicago, IL, USA., Li Y; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Lin Z; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Pla I; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA., Gajjela R; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA., Mattamana BB; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA., Joshi M; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA., Liu Y; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA., Wang H; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA., Zun AB; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA., Wang H; Molecular Oncology Laboratory, Department of Orthopedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, USA., Wai CM; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Agrawal V; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.; Center for Physical Genomics and Engineering, Northwestern University, Evanston, IL, USA., Dunton CL; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.; Center for Physical Genomics and Engineering, Northwestern University, Evanston, IL, USA., Duan C; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA., Jiang B; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.; Querrey Simpson Institute for Regenerative Engineering at Northwestern University, Northwestern University, Chicago, IL, USA.; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Backman V; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.; Querrey Simpson Institute for Regenerative Engineering at Northwestern University, Northwestern University, Chicago, IL, USA.; Center for Physical Genomics and Engineering, Northwestern University, Evanston, IL, USA.; Chemistry of Life Process Institute, Northwestern University, Evanston, IL, USA., He TC; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Molecular Oncology Laboratory, Department of Orthopedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, USA., Reid RR; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Laboratory of Craniofacial Biology and Development, Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medical Center, Chicago, IL, USA., Luo Y; Querrey Simpson Institute for Regenerative Engineering at Northwestern University, Northwestern University, Chicago, IL, USA.; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Northwestern University Clinical and Translational Sciences Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Collaborative AI in Healthcare, Institute for AI in Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Ameer GA; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA. g-ameer@northwestern.edu.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA. g-ameer@northwestern.edu.; Querrey Simpson Institute for Regenerative Engineering at Northwestern University, Northwestern University, Chicago, IL, USA. g-ameer@northwestern.edu.; Center for Physical Genomics and Engineering, Northwestern University, Evanston, IL, USA. g-ameer@northwestern.edu.; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. g-ameer@northwestern.edu.; Northwestern University Clinical and Translational Sciences Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. g-ameer@northwestern.edu.; International Institute for Nanotechnology, Northwestern University, Evanston, IL, USA. g-ameer@northwestern.edu.
Source: Nature communications [Nat Commun] 2025 Jul 11; Vol. 16 (1), pp. 6444. Date of Electronic Publication: 2025 Jul 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome.
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Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Joshi+M%22">Joshi M</searchLink>; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zun+AB%22">Zun AB</searchLink>; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; 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Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.; Querrey Simpson Institute for Regenerative Engineering at Northwestern University, Northwestern University, Chicago, IL, USA.; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Backman+V%22">Backman V</searchLink>; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.; Querrey Simpson Institute for Regenerative Engineering at Northwestern University, Northwestern University, Chicago, IL, USA.; Center for Physical Genomics and Engineering, Northwestern University, Evanston, IL, USA.; Chemistry of Life Process Institute, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22He+TC%22">He TC</searchLink>; 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International Institute for Nanotechnology, Northwestern University, Evanston, IL, USA. g-ameer@northwestern.edu.
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