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Phase 1 first-in-human dose-expansion study of the oral SF3B1 modulator H3B‑8800 in lower-risk myelodysplastic syndrome.

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Title: Phase 1 first-in-human dose-expansion study of the oral SF3B1 modulator H3B‑8800 in lower-risk myelodysplastic syndrome.
Authors: Foran JM; Division of Hematology & Medical Oncology, Mayo Clinic Florida, Jacksonville, FL, USA. Electronic address: Foran.James@mayo.edu., Sanz GF; Department of Haematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Health Research Institute La Fe, Valencia, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain., Watts JM; University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL, USA., Brunner AM; Center for Leukemia, Massachusetts General Hospital, Boston, MA, USA., Fossard G; Service d'Hématologie Clinique, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre Bénite, France., Della Porta MG; Cancer Center IRCCS Humanitas Research Hospital, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Tsai XC; National Taiwan University Hospital, No. 7, Taipei, Taiwan., Garcia-Manero G; Section of MDS, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dimicoli-Salazar S; Hôpital Haut-Lévêque, Service d'Hématologie Clinique et Thérapie Cellulaire, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France., Fletcher L; Willamette Valley Cancer Institute and US Oncology Research Center, Eugene, OR, USA., Kim YJ; Acute Leukemia Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea., Font P; Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Alfonso-Piérola A; Hematology and Cell Therapy Service, Cancer Center Clínica Universidad de Navarra (CCUN), IdISNA, Pamplona, Spain., Alonso-Dominguez JM; Hospital Universitario Fundación Jiménez Díaz - IIS-FJD, Madrid, Spain., Benton C; Rocky Mountain Cancer Centers, US Oncology Network, Denver, CO, USA., Hong J; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea., Malcovati L; Department of Hematology, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Mazure D; Department of Hematology, Ghent University Hospital, Ghent, Belgium., Lee JH; Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Yeh SP; Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan., Goursaud L; Department of Hematology, CHU LILLE, Lille, France., Barcellini W; Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Wu E; Roivant Sciences, New York, NY, USA., Corzo D; Roivant Sciences, New York, NY, USA., Kuida K; Hemavant Sciences, Basel, Switzerland., Stone RM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Source: Leukemia research [Leuk Res] 2025 Sep; Vol. 156, pp. 107735. Date of Electronic Publication: 2025 Jun 09.
Publication Type: Journal Article; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 7706787 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5835 (Electronic) Linking ISSN: 01452126 NLM ISO Abbreviation: Leuk Res Subsets: MEDLINE
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  Data: Phase 1 first-in-human dose-expansion study of the oral SF3B1 modulator H3B‑8800 in lower-risk myelodysplastic syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Foran+JM%22">Foran JM</searchLink>; Division of Hematology & Medical Oncology, Mayo Clinic Florida, Jacksonville, FL, USA. Electronic address: Foran.James@mayo.edu.<br /><searchLink fieldCode="AU" term="%22Sanz+GF%22">Sanz GF</searchLink>; Department of Haematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Health Research Institute La Fe, Valencia, Spain; CIBERONC, Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Watts+JM%22">Watts JM</searchLink>; University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Brunner+AM%22">Brunner AM</searchLink>; Center for Leukemia, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fossard+G%22">Fossard G</searchLink>; Service d'Hématologie Clinique, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre Bénite, France.<br /><searchLink fieldCode="AU" term="%22Della+Porta+MG%22">Della Porta MG</searchLink>; Cancer Center IRCCS Humanitas Research Hospital, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tsai+XC%22">Tsai XC</searchLink>; National Taiwan University Hospital, No. 7, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Garcia-Manero+G%22">Garcia-Manero G</searchLink>; Section of MDS, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Dimicoli-Salazar+S%22">Dimicoli-Salazar S</searchLink>; Hôpital Haut-Lévêque, Service d'Hématologie Clinique et Thérapie Cellulaire, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Fletcher+L%22">Fletcher L</searchLink>; Willamette Valley Cancer Institute and US Oncology Research Center, Eugene, OR, USA.<br /><searchLink fieldCode="AU" term="%22Kim+YJ%22">Kim YJ</searchLink>; Acute Leukemia Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Font+P%22">Font P</searchLink>; Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Alfonso-Piérola+A%22">Alfonso-Piérola A</searchLink>; Hematology and Cell Therapy Service, Cancer Center Clínica Universidad de Navarra (CCUN), IdISNA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Alonso-Dominguez+JM%22">Alonso-Dominguez JM</searchLink>; Hospital Universitario Fundación Jiménez Díaz - IIS-FJD, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Benton+C%22">Benton C</searchLink>; Rocky Mountain Cancer Centers, US Oncology Network, Denver, CO, USA.<br /><searchLink fieldCode="AU" term="%22Hong+J%22">Hong J</searchLink>; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Malcovati+L%22">Malcovati L</searchLink>; Department of Hematology, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Mazure+D%22">Mazure D</searchLink>; Department of Hematology, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Yeh+SP%22">Yeh SP</searchLink>; Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Goursaud+L%22">Goursaud L</searchLink>; Department of Hematology, CHU LILLE, Lille, France.<br /><searchLink fieldCode="AU" term="%22Barcellini+W%22">Barcellini W</searchLink>; Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Wu+E%22">Wu E</searchLink>; Roivant Sciences, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Corzo+D%22">Corzo D</searchLink>; Roivant Sciences, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kuida+K%22">Kuida K</searchLink>; Hemavant Sciences, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stone+RM%22">Stone RM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%227706787%22">Leukemia research</searchLink> [Leuk Res] 2025 Sep; Vol. 156, pp. 107735. <i>Date of Electronic Publication: </i>2025 Jun 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Pergamon+Press%22">Pergamon Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>7706787 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-5835 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201452126%22">01452126 </searchLink><i>NLM ISO Abbreviation: </i>Leuk Res <i>Subsets: </i>MEDLINE
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