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Lifestyle, Early-life, and Genetic Health Risk Factors Underlying the Brain Age Gap: A Mega-Analysis Across 3,934 Individuals from the ENIGMA MDD Consortium.

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Title: Lifestyle, Early-life, and Genetic Health Risk Factors Underlying the Brain Age Gap: A Mega-Analysis Across 3,934 Individuals from the ENIGMA MDD Consortium.
Authors: Han LKM; Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands.; Amsterdam Public Health, Mental Health program, Amsterdam, The Netherlands.; Centre for Youth Mental Health, The University of Melbourne, Parkville, Australia.; Orygen, Parkville, Australia., Toenders YJ; Erasmus School of Social and Behavioral Sciences, Erasmus University Rotterdam, the Netherlands., Shen X; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh., Milaneschi Y; Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands.; Amsterdam Public Health, Mental Health program, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Complex Trait Genetics, Amsterdam, The Netherlands., Whalley HC; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh.; Generation Scotland, Centre for Medical Informatics, University of Edinburgh., Sämann PG; Department of Translational Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Andlauer T; Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich., Bauer J; Clinic for Radiology, University of Münster, Münster, Germany., Berger K; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Borgers T; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Cole JH; Hawkes Institute, Department of Computer Science, University College London.; Dementia Research Centre, Queen Square Institute of Neurology, University College London., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Flinkenflügel K; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Gruber O; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany., Hahn T; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Hamilton PJ; Department of Medical and Biological Psychology, University of Bergen., Hatton SN; Brain and Mind Centre, University of Sydney, Australia., Hermesdorf M; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Hickie I; Brain and Mind Centre, University of Sydney, Australia., Homann J; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Kircher TJ; Department of Psychiatry, University of Marburg, Germany., Krämer B; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Centre for Psychosocial Medicine, Heidelberg University, Heidelberg, Germany., Kraus A; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Krug A; Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany., Lill CM; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London., Medland SE; QIMR Berghofer, Brisbane, Australia., Meinert S; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Institute for Translational Neuroscience, University of Münster, Münster, Germany., Panzenhagen A; Department of Translational Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Programa de Pós-graduação em Ciências Biológicas: Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Penninx BWJH; Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands.; Amsterdam Public Health, Mental Health program, Amsterdam, The Netherlands., van der Wee NJA; Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands.; Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, the Netherlands., van Tol MJ; Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Research School of Behavioural and Cognitive Neurosciences, University of Groningen, Groningen, the Netherlands., Völker U; University Medicine Greifswald, Interfaculty Institute for Genetics and Functional Genomics, Department Functional Genomics, Greifswald, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Weihs A; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Germany., Wittfeld K; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Thomopoulos SI; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, CA, USA., Jahanshad N; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, CA, USA.; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California., Thompson PM; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, CA, USA., Pozzi E; Centre for Youth Mental Health, The University of Melbourne, Parkville, Australia.; Orygen, Parkville, Australia., Schmaal L; Centre for Youth Mental Health, The University of Melbourne, Parkville, Australia.; Orygen, Parkville, Australia.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 May 11. Date of Electronic Publication: 2025 May 11.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
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