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Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer's disease models.

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Title: Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer's disease models.
Authors: Pallapati AR; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Korkmaz F; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Rojekar S; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Sims S; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Misra A; Greehey Children's Cancer Research Institute and.; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Gimenez-Roig J; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Gangadhar A; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Laurencin V; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Gumerova A; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Cheliadinova U; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Sultana F; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Vasilyeva D; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Cullen L; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Schuermann J; Northeastern Collaborative Access Team, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA., Munitz J; BioMedical Engineering and Imaging Institute., Kannangara H; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Parte S; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Pevnev G; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Burganova G; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Tumoglu Z; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Witztum R; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Wizman S; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Kramskiy N; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Igel L; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Sen F; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Ranzenigo A; BioMedical Engineering and Imaging Institute., Macdonald A; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Hutchison S; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Teunissen AJ; BioMedical Engineering and Imaging Institute.; Cardiovascular Research Institute.; Icahn Genomics Institute, and., Burkart H; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Saxena M; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Ginsburg Y; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Goosens K; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Zhou W; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Ryu V; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Moldavski O; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Barak O; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Pazianas M; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Caminis J; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Bhasin S; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Fitzgerald R; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom., Kim SM; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Quinn M; Department of Pathology-Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Haider S; School of Pharmacy, University College London, London, United Kingdom., Appt S; Department of Pathology-Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Frolinger T; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Rosen CJ; MaineHealth Institute for Research, Scarborough, Maine, USA., Lizneva D; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Gupta YK; Greehey Children's Cancer Research Institute and.; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Yuen T; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and., Zaidi M; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2025 Jul 15; Vol. 135 (17). Date of Electronic Publication: 2025 Jul 15 (Print Publication: 2025).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer's disease models.
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  Data: <searchLink fieldCode="AU" term="%22Pallapati+AR%22">Pallapati AR</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Korkmaz+F%22">Korkmaz F</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Rojekar+S%22">Rojekar S</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Sims+S%22">Sims S</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Misra+A%22">Misra A</searchLink>; Greehey Children's Cancer Research Institute and.; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Gimenez-Roig+J%22">Gimenez-Roig J</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Gangadhar+A%22">Gangadhar A</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Laurencin+V%22">Laurencin V</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Gumerova+A%22">Gumerova A</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Cheliadinova+U%22">Cheliadinova U</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Sultana+F%22">Sultana F</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; 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Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Pevnev+G%22">Pevnev G</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Burganova+G%22">Burganova G</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Tumoglu+Z%22">Tumoglu Z</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Witztum+R%22">Witztum R</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Wizman+S%22">Wizman S</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; 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Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Teunissen+AJ%22">Teunissen AJ</searchLink>; BioMedical Engineering and Imaging Institute.; Cardiovascular Research Institute.; Icahn Genomics Institute, and.<br /><searchLink fieldCode="AU" term="%22Burkart+H%22">Burkart H</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Saxena+M%22">Saxena M</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Ginsburg+Y%22">Ginsburg Y</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Goosens+K%22">Goosens K</searchLink>; 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Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.<br /><searchLink fieldCode="AU" term="%22Zaidi+M%22">Zaidi M</searchLink>; Mount Sinai Center for Translational Medicine and Pharmacology.; Department of Pharmacological Sciences, and.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
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